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Updated: Jun 26, 2026

A Novel Digital Platform for a Monitored Home-based Cardiac Rehabilitation Program

A Novel Digital Platform for a Monitored Home-based Cardiac Rehabilitation Program

Published on: April 19, 2019

Home-Based Combined Activity and Cognitive Intervention for Post-Intensive Care Syndrome: A Pilot Randomised

Polly W C Li¹, C K Tong², Peter C K Lai^3,4

¹School of Nursing, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.

Nursing in Critical Care

|June 25, 2026

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The COMBAT-ICU program, a home-based intervention combining physical and cognitive training, effectively reduced post-intensive care syndrome (PICS) in survivors. This multidomain approach shows promise for enhancing recovery and survivorship care.

Area of Science:

Critical Care Medicine
Rehabilitation Science
Neuroscience

Background:

Post-intensive care syndrome (PICS) affects ICU survivors with persistent physical, cognitive, and psychological impairments, limiting recovery and quality of life.
Current rehabilitation strategies are often exercise-focused and fail to address the multifaceted nature of PICS.
A novel, multidomain approach is needed to improve outcomes for ICU survivors.

Purpose of the Study:

To assess the feasibility and preliminary efficacy of COMBAT-ICU, a home-based combined physical activity and cognitive intervention for ICU survivors at risk of PICS.
To evaluate the safety and adherence of the COMBAT-ICU program.
To explore the impact of COMBAT-ICU on PICS severity, physical function, cognition, mental health, and quality of life.

Main Methods:

Keywords:

ICU survivors cognitive rehabilitation combined exercise and cognitive intervention home‐based rehabilitation post‐intensive care syndrome

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Last Updated: Jun 26, 2026

A Novel Digital Platform for a Monitored Home-based Cardiac Rehabilitation Program

A Novel Digital Platform for a Monitored Home-based Cardiac Rehabilitation Program

Published on: April 19, 2019

A pilot randomized controlled trial involving 36 ICU survivors randomized into three arms: COMBAT-ICU, exercise-only, or attention control.
The COMBAT-ICU intervention consisted of an 8-week blended program of progressive physical exercise and computerized cognitive training, delivered via home visits and online sessions.
Feasibility (recruitment, retention, adherence) and safety were primary outcomes, with secondary exploratory outcomes including PICS severity, physical capacity, cognition, mental health, and health-related quality of life (HRQoL).

Main Results:

The COMBAT-ICU intervention was feasible and safe, with high retention (>82%) and adherence (>90%) rates.
COMBAT-ICU significantly reduced PICS severity compared to the attention control group at post-intervention and follow-up.
Clinically meaningful improvements were observed in walking endurance, global cognition, short-term memory, and HRQoL compared to attention control, with superior cognitive and HRQoL outcomes compared to the exercise-only group.

Conclusions:

The COMBAT-ICU program is a feasible and safe home-based rehabilitation strategy for ICU survivors at risk of PICS.
Integrating cognitive and physical training demonstrates synergistic benefits, potentially exceeding those of exercise alone.
COMBAT-ICU shows promising preliminary efficacy in mitigating PICS and warrants further investigation in large-scale multicenter trials.