Related Experiment Videos
A Review on the Bioavailability, Bioefficacies, and Delivery Systems for Sanshools, the Main Numbing Substances in
Chun Ding1, Chi-Tang Ho2, Yawen Wang3
1Guangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods, College of Food Science, South China Agricultural University, Guangzhou 510642, China.
Abstract:
Zanthoxylum bungeanum, commonly known as Chinese pepper, widely used globally as a spice for its unique numbing-tingling sensation and flavor-enhancing properties, owes its key biological activity to sanshool, a major polyunsaturated fatty acid amide component, mainly present in its pericarps. This work comprehensively examines and summarizes sanshool's distribution, biosynthesis, stability, and bioavailability, while reviewing and discussing its potent biological functions and underlying molecular mechanisms, including antioxidation, analgesia, anti-inflammation, antiobesity, and antidiabetic effects. Various delivery systems for improving the stability and bioavailability of sanshool are also summarized and evaluated, including nanoparticles, liposomes, and emulsions. This study aims to provide a comprehensive understanding of sanshool's physiochemical properties and health benefits, facilitating its greater application in the food and nutraceutical industries.
Related Concept Videos
Drug Delivery: Enteral Route
Drugs in...
Bioavailability Enhancement: Drug Solubility Enhancement
Bioavailability Enhancement: Drug Permeability Enhancement
Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems
Bioavailability: Overview
Bioavailability: Overview