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Related Experiment Video

Updated: Jun 26, 2026

Preparation of Parasagittal Slices for the Investigation of Dorsal-ventral Organization of the Rodent Medial Entorhinal Cortex

Preparation of Parasagittal Slices for the Investigation of Dorsal-ventral Organization of the Rodent Medial Entorhinal Cortex

Published on: March 28, 2012

Coordinating Cognition: The Entorhinal Cortex in Mnemonic, Temporal and Spatial Representation.

Sara Marcoccia^1,2, Giulia Chiacchierini^1,2, Patrizia Campolongo^1,2

¹Department of Physiology and Pharmacology, Sapienza University of Rome, 00185 Rome, Italy.

|June 25, 2026

Summary

The entorhinal cortex (EC), crucial for memory and navigation, integrates medial (MEC) and lateral (LEC) regions. This dynamic system structures experiences across space and time, vital for healthy brain function.

Keywords:

LEC MEC connectivity entorhinal cortex memory navigation time processing

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Assessment of Memory Function in Pilocarpine-induced Epileptic Mice

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice

Published on: June 4, 2020

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Last Updated: Jun 26, 2026

Preparation of Parasagittal Slices for the Investigation of Dorsal-ventral Organization of the Rodent Medial Entorhinal Cortex

Preparation of Parasagittal Slices for the Investigation of Dorsal-ventral Organization of the Rodent Medial Entorhinal Cortex

Published on: March 28, 2012

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice

Published on: June 4, 2020

Area of Science:

Neuroscience
Cognitive Science
Memory Research

Background:

The entorhinal cortex (EC) is a key medial temporal lobe structure.
It serves as the primary cortical gateway to the hippocampus (HPC).
The EC is vital for memory, spatial navigation, and temporal representation.

Purpose of the Study:

To review the distinct and complementary roles of the medial (MEC) and lateral (LEC) entorhinal cortices.
To highlight the coordinated function of MEC and LEC in memory and navigation.
To present an updated view of the EC as an integrated system.

Main Methods:

Literature review of recent findings on EC function.
Analysis of the EC's layered architecture and microcircuitry.
Examination of EC interactions with hippocampal, cortical, and subcortical networks.

Main Results:

MEC specializes in spatial mapping and movement, LEC in object/context processing.
MEC encodes time via cell sequences; LEC uses rate remapping for temporal context.
Evidence shows significant integration between MEC and LEC, challenging functional segregation.

Conclusions:

The EC functions as a coordinated, interactive system, not parallel modules.
This integration is essential for encoding and retrieving multidimensional experiences.
Altered EC activity is an early indicator of neurological diseases like Alzheimer's.