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Inflammatory and Infectious Cutaneous Entities Resembling Cutaneous T-Cell Lymphoma (CTCL): An Integrated
Jade Nasser Eldin1, Elias El Tayar1, Ossama Abbas1
1Dermatology Department, American University of Beirut-Medical Center, Beirut P.O. Box 11-0236, Lebanon.
Dermatopathology (Basel, Switzerland)
|June 25, 2026
Summary
Cutaneous pseudolymphomas mimic cutaneous lymphomas, posing diagnostic challenges. Differentiating these benign conditions from CTCLs (cutaneous T-cell lymphomas) is vital to prevent misdiagnosis and overtreatment.
Area of Science:
- Dermatology
- Oncology
- Pathology
Background:
- Cutaneous pseudolymphomas are benign lymphoid proliferations.
- They can clinically and histologically resemble cutaneous lymphomas.
- Distinguishing them from CTCLs (cutaneous T-cell lymphomas) is challenging.
Purpose of the Study:
- To review clinicopathologic features of inflammatory and infectious dermatoses mimicking CTCL.
- To provide strategies for differentiating true lymphoma from pseudolymphoma.
- To highlight the importance of clinicopathologic correlation.
Main Methods:
- Comprehensive literature review.
- Analysis of clinicopathologic features of pseudolymphomas.
- Comparison with CTCL, particularly mycosis fungoides (MF).
Main Results:
- Various inflammatory, infectious, and drug-induced dermatoses can mimic CTCL.
- Mimickers may exhibit epidermotropism, dense infiltrates, or clonality.
- Accurate differentiation is crucial to avoid overtreatment.
Conclusions:
- Clinicopathologic correlation is essential for accurate diagnosis.
- Understanding features of pseudolymphoma aids in distinguishing it from CTCL.
- This review offers practical strategies for differentiation.
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