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Related Concept Videos

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Rheumatic Heart Disease III: Medical Management01:21

Rheumatic Heart Disease III: Medical Management

Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...

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Related Experiment Videos

Subclinical Myocardial Dysfunction Post Kawasaki Disease: A Systematic Review and Meta-Analysis.

Dafni Charisopoulou1, Sotiria Iliopoulou2, Stelina Al Kagiet2

  • 12nd Department of Paediatrics, AHEPA University General Hospital, School of Medicine, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.

Diseases (Basel, Switzerland)
|June 25, 2026
PubMed
Summary

Children with a history of Kawasaki disease (KD) show reduced left ventricular global longitudinal strain (GLS), indicating persistent subclinical myocardial dysfunction. Speckle-tracking echocardiography can aid long-term cardiac assessment in these patients.

Keywords:
Kawasaki diseaseglobal longitudinal strainmeta-analysismyocardial dysfunctionspeckle-tracking echocardiography

Related Experiment Videos

Area of Science:

  • Cardiology
  • Pediatric Medicine
  • Echocardiography

Background:

  • Kawasaki disease (KD) is a childhood vasculitis known for coronary artery issues.
  • Subtle, long-term myocardial dysfunction can persist in KD survivors, even with normal systolic function.
  • Two-dimensional speckle-tracking echocardiography (2D-STE) offers sensitive assessment of left ventricular global longitudinal strain (GLS).

Purpose of the Study:

  • To systematically review and meta-analyze studies on post-acute GLS in children with prior KD.
  • To compare GLS in children with KD history versus healthy controls.
  • To determine if KD history is associated with subclinical myocardial dysfunction via GLS.

Main Methods:

  • Systematic review and meta-analysis adhering to PRISMA 2020 guidelines.
  • Searched PubMed, Scopus, Web of Science, and Google Scholar for relevant case-control studies.
  • Analyzed GLS using random-effects models, calculating the mean difference (MD) between KD patients and controls.

Main Results:

  • Included 4 studies with 192 KD patients and 138 controls.
  • KD patients exhibited significantly less negative GLS (pooled MD: 0.77%, p=0.019), indicating impaired longitudinal deformation.
  • Low heterogeneity (I²=5.3%) supported the robustness of the findings.

Conclusions:

  • Children and adolescents with KD history have a significant, albeit modest, reduction in LV GLS.
  • This reduction suggests persistent subclinical myocardial dysfunction post-KD.
  • 2D-STE (GLS) may enhance long-term cardiac surveillance for selected KD survivors.