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Related Experiment Video

Updated: Jun 26, 2026

Treatment with Locking Intramedullary Nailing for Intertrochanteric Fracture of the Femur Utilizing a New Awl with a Distal Positioner
04:41

Treatment with Locking Intramedullary Nailing for Intertrochanteric Fracture of the Femur Utilizing a New Awl with a Distal Positioner

Published on: June 6, 2025

Intramedullary Nailing Versus Modular Megaprosthesis in Pathological Humeral Fractures: A 10-Year Retrospective

Giuseppe Rovere1,2, Federica Messina3,4, Cesare Meschini4,5

  • 1Orthopaedic Unit, Department of Surgical Sciences, University Hospital of Tor Vergata, 00133 Rome, Italy.

Diseases (Basel, Switzerland)
|June 25, 2026
PubMed
Summary
This summary is machine-generated.

Intramedullary nailing offers faster initial recovery for humeral fractures, while megaprosthesis provides a durable solution for extensive tumors. Both surgical options achieve comparable long-term functional outcomes for pathological fractures.

Keywords:
MSTSQuickDASHWOSIfunctional outcomeshumeral metastasesintramedullary nailingmegaprosthesisorthopedic oncologypathological fracturessurvival analysis

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Last Updated: Jun 26, 2026

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A Minimally Invasive Model to Analyze Endochondral Fracture Healing in Mice Under Standardized Biomechanical Conditions

Published on: March 22, 2018

Area of Science:

  • Orthopedic Surgery
  • Oncology
  • Reconstructive Surgery

Background:

  • Pathological humeral fractures from metastatic disease cause significant pain and disability.
  • Surgical goals include pain reduction, stability restoration, and early mobilization.
  • The choice between intramedullary nailing and megaprosthesis for humeral fractures is debated.

Purpose of the Study:

  • To compare functional outcomes and complications of intramedullary nailing versus megaprosthesis for pathological humeral fractures.
  • To evaluate early and long-term results of surgical management for humeral fractures.
  • To inform individualized treatment decisions based on fracture characteristics.

Main Methods:

  • Retrospective study of 48 patients with pathological or impending humeral fractures.
  • Comparison of intramedullary nailing (26 patients) and modular megaprosthesis (22 patients).
  • Functional outcomes assessed using MSTS, QuickDASH, and WOSI scores; complications and survival analyzed.

Main Results:

  • Intramedullary nailing showed superior early functional outcomes (MSTS, QuickDASH, WOSI).
  • Megaprosthesis had slower initial recovery but comparable long-term functional outcomes.
  • Overall complication rates were similar, but periprosthetic infections occurred only with megaprosthesis.

Conclusions:

  • Both intramedullary nailing and megaprosthesis are effective for pathological humeral fractures.
  • Intramedullary nailing offers faster early recovery; megaprosthesis is suitable for extensive lesions.
  • Treatment decisions should be individualized based on lesion characteristics and patient factors.