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Updated: Jun 26, 2026
06:32
Evaluation of Coronary Flow Reserve After Myocardial Ischemia Reperfusion in Rats
Published on: June 28, 2019
Patients with Restless Leg Syndrome Have Lower Coronary Flow Velocity Reserve Compared to Healthy Controls:
Göksel Güz1, Rasim Onur Karaoğlu2, Sezen Kumaş Solak2
1Department of Cardiology, Medicana International Hospital, 34520 Istanbul, Turkey.
Journal of Cardiovascular Development and Disease
|June 25, 2026
Summary
Restless leg syndrome (RLS) is linked to poorer coronary endothelial function, indicated by lower coronary flow velocity reserve (CFVR). This suggests RLS patients may benefit from cardiac monitoring.
Area of Science:
- Cardiology
- Neurology
- Vascular Medicine
Background:
- Restless leg syndrome (RLS) is associated with increased vascular disorder risk.
- Endothelial dysfunction is implicated in RLS pathogenesis.
Purpose of the Study:
- To evaluate coronary endothelial dysfunction in RLS patients.
- To compare coronary flow velocity reserve (CFVR) in RLS patients versus healthy controls.
Main Methods:
- 42 RLS patients and 41 healthy controls were studied.
- Coronary flow velocity reserve (CFVR) was the primary outcome.
- Correlations between CFVR, RLS severity (IRLS), WBC, and CRP were analyzed.
Main Results:
- RLS patients exhibited significantly lower CFVR than controls (p < 0.001).
- 14 RLS patients (33%) had CFVR < 2.0, versus 0 controls (p < 0.001).
- Higher WBC and CRP levels were observed in RLS patients, with a negative correlation between CFVR and IRLS (p < 0.001).
Conclusions:
- RLS patients demonstrate impaired coronary endothelial function.
- A negative correlation exists between RLS severity and CFVR.
- Further research is needed, but RLS patients may benefit from coronary heart disease monitoring.
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