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Published on: November 14, 2020
Short-Term Cardiac Effects of Bariatric Surgery: Is Weight Loss Alone Sufficient in Metabolically Healthy Morbidly
Omer Ozkan Duman1, Ummu Taş1, Sedat Taş1
1Department of Cardiology, İzmir Demokrasi University, Buca Research and Training Hospital, 35390 İzmir, Turkey.
Insights
Bariatric surgery significantly improves cardiac structure and function in metabolically healthy obese individuals by reducing adipose tissue. This weight loss reverses negative heart remodeling, lowering cardiovascular risk without comorbidities.
Area of Science:
- Cardiology
- Bariatric Surgery
- Obesity Medicine
Background:
- Obesity is a major cardiovascular disease risk factor.
- Comorbidities like diabetes and hypertension obscure obesity's direct cardiac impact.
- The study focuses on metabolically healthy obese (MHO) individuals to isolate obesity's effects.
Purpose of the Study:
- To evaluate the isolated effects of weight loss from bariatric surgery on left ventricular (LV) geometry and diastolic function.
- To assess cardiac remodeling in MHO patients post-bariatric surgery.
- To understand the impact of reduced adipose tissue and hemodynamic load on the heart.
Main Methods:
- Included 28 MHO patients undergoing Laparoscopic Sleeve Gastrectomy (LSG) (BMI > 40 kg/m²).
- A control group of 25 MHO patients without surgery was matched for age and gender.
- Echocardiographic and demographic data were analyzed at baseline and 6 months post-surgery.
Main Results:
- Surgical group showed significant BMI reduction (46.21 to 37.11 kg/m²) and decreased Left Ventricular Mass Index (51.11 to 44.57 g/m²).
- Diastolic function improved, indicated by a significant increase in the E/A ratio (1.19 to 1.34).
- Marked improvements in glucose and lipid profiles were observed in the surgical group.
Conclusions:
- Bariatric surgery induces cardiac reverse remodeling and improves function in MHO patients, independent of metabolic comorbidities.
- Weight loss through bariatric surgery directly reduces adipose tissue and alleviates hemodynamic load on the heart.
- Surgery is effective in reducing cardiovascular risk and preserving cardiac structure in morbidly obese individuals without comorbidities.
Abstract:
Background: Obesity is an independent and major risk factor for cardiovascular diseases. However, the presence of common comorbidities such as diabetes and hypertension makes it difficult to understand the direct impact of obesity on the myocardium. The aim of this study is to evaluate the isolated effects of weight loss achieved after bariatric surgery on left ventricular (LV) geometry and diastolic functions in individuals with the "Metabolically Healthy Obese" (MHO) phenotype. Materials and Methods: The study included 28 patients (Surgical Group) who underwent Laparoscopic Sleeve Gastrectomy (LSG) between January 2022 and December 2025, had a preoperative Body Mass Index (BMI) > 40 kg/m2, and had no known cardiovascular or metabolic diseases. The control group consisted of 25 age- and gender-matched metabolically healthy morbidly obese patients who had not undergone surgery. Demographic and echocardiographic data of all participants were analyzed at baseline and at 6 months. Results: Weight Loss: In the surgical group, BMI decreased from 46.21 kg/m2 to 37.11 kg/m2 at the 6th month, while no significant change was observed in the control group. Cardiac Structure: In the surgical group, Left Ventricular Mass Index was significantly decreased from 51.11 g/m2 to 44.57 g/m2. Cardiac Function: The E/A ratio, an indicator of diastolic function, increased significantly from 1.19 to 1.34 in the surgical group, indicating notable improvement. No clinically meaningful change in systolic function was detected. Metabolic Parameters: The surgical group exhibited marked improvements in glucose and lipid profiles (decrease in Total Cholesterol, increase in HDL). Conclusions: The study demonstrates that bariatric surgery, independent of metabolic comorbidities, directly provides "reverse remodeling" of cardiac structure and improves function through reduction of adipose tissue and alleviation of hemodynamic load. These results support the effectiveness of surgery in reducing cardiovascular risk and preserving cardiac structure even in morbidly obese patients without comorbidities.
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