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Related Experiment Video

Updated: Jun 26, 2026

Intraductal Delivery to the Rabbit Mammary Gland
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Intraductal Delivery to the Rabbit Mammary Gland

Published on: March 9, 2017

Recurrence Patterns and Overtreatment in Pure DCIS: A Retrospective Clinical and Radiological Follow-Up Study.

Maria Concetta Torrione1, Andrea Gaia Azzarito1, Vanessa Marisi2

  • 1Unit of Radiology, "Santissima Annunziata" Hospital, 66100 Chieti, Italy.

Journal of Personalized Medicine
|June 25, 2026
PubMed
Summary

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This summary is machine-generated.

Recurrence of ductal carcinoma in situ (DCIS) after treatment is uncommon, often non-invasive, and linked to estrogen receptor-positive status. Current methods may not fully predict recurrence risk, suggesting a need for personalized risk assessment in DCIS management.

Area of Science:

  • Oncology
  • Breast Cancer Research
  • Clinical Pathology

Background:

  • Ductal carcinoma in situ (DCIS) management is challenging due to variable progression risk.
  • Standard treatments like surgery and radiotherapy have inconsistent recurrence outcomes.
  • Identifying factors influencing DCIS recurrence is crucial for optimizing patient care.

Purpose of the Study:

  • To analyze recurrence patterns in a large cohort of pure DCIS patients.
  • To identify clinicopathological factors associated with ipsilateral recurrence.
  • To evaluate the effectiveness of current treatment strategies for DCIS.

Main Methods:

  • Retrospective analysis of 403 patients with pure DCIS (2016-2023).
  • Inclusion of patients treated with breast-conserving surgery or mastectomy.
Keywords:
DCISbreast cancerfollow-uplocal recurrenceovertreatmentradiotherapy

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Last Updated: Jun 26, 2026

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  • Assessment of clinical, imaging, pathological, and treatment data; comparative analyses for recurrence.

    • Main Results:

    • 5% (21/403) ipsilateral recurrence rate observed.
    • Recurrences included 57% non-invasive DCIS and 38% invasive carcinoma.
    • Higher recurrence in breast-conserving surgery patients; 52% lacked radiotherapy; all recurrent cases were ER-positive.

    Conclusions:

    • Pure DCIS recurrence is infrequent and often non-invasive.
    • Clinicopathological factors alone are insufficient for predicting recurrence.
    • Individualized risk stratification using integrated factors is needed to avoid overtreatment.