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Related Experiment Videos

Risk-Guided Personalized Care to Prevent Bronchopulmonary Dysplasia: A Real-World Implementation Study.

Avram R Shack^1,2, Tapas Kulkarni^1,2, Alyssa Hawley³

¹Division of Neonatology, Department of Pediatrics, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.

Journal of Personalized Medicine

|June 25, 2026

Summary

A new strategy improved care for premature infants at risk of bronchopulmonary dysplasia (BPD) by guiding interventions. This approach enhanced teamwork and care coordination without worsening clinical outcomes.

Keywords:

RE-AIM framework bronchopulmonary dysplasia implementation strategies neonates personalized medicine risk stratification

Related Experiment Videos

Area of Science:

Neonatology
Pediatric Pulmonology
Healthcare Implementation Science

Background:

Bronchopulmonary dysplasia (BPD) is a significant cause of illness in extremely premature infants.
There is considerable variation in how evidence-based interventions for BPD are applied in neonatal intensive care units (NICUs).
A standardized, risk-guided approach is needed to personalize BPD prevention strategies.

Purpose of the Study:

To evaluate a multi-component, risk-guided personalized implementation strategy for BPD prevention.
To assess the strategy's effectiveness in a real-world setting within a quaternary NICU.
To examine implementation outcomes using the RE-AIM framework and explore clinical impacts.

Main Methods:

A prospective observational study included infants born <29 weeks' gestation.
The intervention involved risk stratification and structured longitudinal care planning rounds (LCPRs).
Implementation fidelity and outcomes were assessed using the RE-AIM framework, alongside care processes and provider feedback.

Main Results:

The strategy demonstrated targeted reach, with all high-risk infants receiving LCPRs.
Providers reported enhanced teamwork, care coordination, and confidence.
BPD or mortality rates were comparable between high-risk (LCPR) and lower-risk infants, despite higher illness severity in the LCPR group.

Conclusions:

A multi-component, risk-guided implementation strategy can be effectively integrated into NICU practice.
The strategy improved care processes and maintained clinical outcomes in high-risk infants.
Early sustainability was indicated by continued strategy use beyond the study period.