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Related Concept Videos

Drug Therapy01:28

Drug Therapy

The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Dosage Regimens: Designs and Approaches01:28

Dosage Regimens: Designs and Approaches

Designing a dosage regimen, which refers to the manner of drug administration, is a complex process involving the selection of drug dose, route, and frequency. This process is underpinned by pharmacokinetic parameters derived from tests and population averages. These parameters are then tailored to patient-specific variables such as diagnosis, demographics, and allergy status. Once therapy commences, therapeutic response monitoring is critical and achieved through clinical and physical...
Dosage Regimen: Individualization01:24

Dosage Regimen: Individualization

Individualization in dosing regimens is the customization of medication doses for individual patients. Its necessity arises from the goal of maximizing therapeutic benefits while minimizing risks. This approach is pivotal because human responses to drugs can vary widely; what is effective for one person may be inadequate or excessive for another. Interpatient (intersubject) variability refers to differences in drug responses between individuals, while intrapatient (intrasubject) variability...
Community Based Intervention01:30

Community Based Intervention

Community-based interventions in mental health represent a paradigm shift from institution-centered care to treatments embedded within the fabric of local communities. By prioritizing inclusion and leveraging existing societal structures, this approach fosters a supportive environment conducive to addressing mental health challenges while promoting individual dignity and agency.
Foundations of Community Mental Health Programs
Central to the success of community-based interventions is the...

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Related Experiment Video

Updated: Jun 26, 2026

The Participant-Reported Implementation Update and Score (PRIUS): A Novel Method for Capturing Implementation-Related Data Over Time
06:05

The Participant-Reported Implementation Update and Score (PRIUS): A Novel Method for Capturing Implementation-Related Data Over Time

Published on: February 19, 2021

Tailoring the CFIR to Medication Adherence Interventions: A Delphi and Living Lab Study.

Mirthe A M Oude Lansink1,2,3, Bart J F van den Bemt1,2,3, Caroline H P A van de Steeg-van Gompel4

  • 1Department of Research, Sint Maartenskliniek, Postbus 9011, 6500 GM Nijmegen, The Netherlands.

Pharmacy (Basel, Switzerland)
|June 25, 2026
PubMed
Summary

Improving medication adherence interventions requires understanding implementation challenges. This study tailored a framework to predict intervention success, finding expert opinions only partially aligned with real-world practice.

Keywords:
community pharmacydeterminant frameworkgeneral practiceimplementationmedication adherenceprimary care

Related Experiment Videos

Last Updated: Jun 26, 2026

The Participant-Reported Implementation Update and Score (PRIUS): A Novel Method for Capturing Implementation-Related Data Over Time
06:05

The Participant-Reported Implementation Update and Score (PRIUS): A Novel Method for Capturing Implementation-Related Data Over Time

Published on: February 19, 2021

Area of Science:

  • Implementation Science
  • Health Services Research
  • Pharmacy Practice

Background:

  • Medication adherence interventions are often poorly implemented.
  • Existing implementation frameworks need context-specific tailoring for effective use.
  • Predicting intervention success requires understanding key implementation determinants.

Purpose of the Study:

  • To tailor the Consolidated Framework for Implementation Research (CFIR) for medication adherence interventions.
  • To assess the predictive accuracy of expert opinion on implementation determinants.
  • To compare expert assessments with real-world implementation outcomes.

Main Methods:

  • A Delphi study was conducted with experts rating CFIR determinants for medication adherence interventions.
  • Four Dutch living labs prospectively evaluated these determinants during intervention implementation.
  • Expert ratings were compared against observed importance in practice.

Main Results:

  • 16 out of 40 CFIR determinants were identified as important across living labs, primarily related to inner setting, individuals, and process.
  • Expert opinions matched real-world practice for only 18 of 40 determinants (45%) regarding importance.
  • The CFIR framework was adapted for primary care medication adherence interventions.

Conclusions:

  • Tailored determinant frameworks can aid in assessing intervention implementability prior to rollout.
  • Expert predictions of implementation importance have limitations; real-world data is crucial.
  • Integrating practice-based evidence enhances the utility of implementation frameworks.