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  1. Home
  3. Human Orthohantavirus Infections: A Narrative Review.
  1. Home
  3. Human Orthohantavirus Infections: A Narrative Review.

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Infection of Primary Nasal Epithelial Cells Grown at an Air-Liquid Interface to Characterize Human Coronavirus-Host Interactions
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Infection of Primary Nasal Epithelial Cells Grown at an Air-Liquid Interface to Characterize Human Coronavirus-Host Interactions

Published on: September 22, 2023

Human Orthohantavirus Infections: A Narrative Review.

Vitor Duque1

  • 1Faculty of Medicine (FMUC), University of Coimbra, 3004-504 Coimbra, Portugal.

Pathogens (Basel, Switzerland)
|June 25, 2026

View abstract on PubMed

Summary
This summary is machine-generated.

Orthohantaviruses, carried by rodents, cause severe human diseases like hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS). Understanding transmission is key for prevention.

Keywords:
emerging infectious diseasesendothelial dysfunctionhantavirushantavirus cardiopulmonary syndromehemorrhagic fever with renal syndromeorthohantaviruszoonosis

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An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

Published on: December 10, 2013

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Infection of Primary Nasal Epithelial Cells Grown at an Air-Liquid Interface to Characterize Human Coronavirus-Host Interactions
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An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
09:01

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

Published on: December 10, 2013

Area of Science:

  • Virology
  • Infectious Diseases
  • Public Health

Background:

  • Orthohantaviruses are zoonotic pathogens in the Hantaviridae family, causing significant human illness.
  • Infections lead to systemic illness, vascular dysfunction, and potentially hemorrhage and multiorgan failure.
  • Disease manifestations include hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS), both with high morbidity and mortality.

Purpose of the Study:

  • To synthesize current knowledge on orthohantaviruses.
  • To cover rodent reservoir competence, viral replication, pathogenesis, and clinical aspects.
  • To review ecological transmission drivers, public health impacts, and future therapeutic challenges.

Main Methods:

  • This is a review article.
  • It synthesizes existing research on orthohantaviruses.
  • Key areas covered include epidemiology, virology, and clinical outcomes.

    • Main Results:

    • Rodents are natural reservoirs, facilitating viral persistence and human spillover via excreta.
    • Transmission occurs through exposure to infected rodent excreta or contaminated environments.
    • Current knowledge covers viral strategies, disease mechanisms, and transmission ecology.

    Conclusions:

    • Understanding orthohantavirus mechanisms is crucial for effective surveillance and risk assessment.
    • Enhanced knowledge aids in developing preventive strategies against these zoonotic infections.
    • Future research should focus on therapeutic developments and addressing transmission challenges.