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Updated: Jun 26, 2026

Synthesis and Calibration of Phosphorescent Nanoprobes for Oxygen Imaging in Biological Systems
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Design, Synthesis, and Performance Characterization of BODIPY-Based NIR Probes for Aβ42 Aggregate Detection.

Jiaoru Chen1, Xueling Ding1, Dezhong Guan2

  • 1Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, P. R. China.

Chempluschem
|June 25, 2026
PubMed
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Researchers developed a novel near-infrared fluorescent probe, BQ-1, for early Alzheimer's disease detection. This probe effectively targets β-amyloid aggregates, offering high sensitivity and signal-to-noise ratio for improved diagnosis.

Area of Science:

  • Neuroscience
  • Chemistry

Background:

  • Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by β-amyloid (Aβ) plaques.
  • Early and accurate detection of cerebral Aβ aggregates is crucial for timely AD intervention but remains challenging.
  • Existing near-infrared imaging tools lack the required sensitivity and signal-to-noise ratio for early Aβ pathological detection.

Purpose of the Study:

  • To design and synthesize novel BODIPY-quinoline-based fluorescent probes for targeting Aβ42 aggregates.
  • To evaluate the performance of these probes for early pathological imaging diagnosis of AD.

Main Methods:

  • Synthesis of two BODIPY-quinoline-based fluorescent probes, BQ-1 and BQ-2.
  • Assessment of probe affinity, sensitivity, and signal-to-noise ratio for Aβ42 aggregates.
Keywords:
Alzheimer’s diseaseAβ aggregatesBODIPYcell imagingnear‐infrared fluorescent probe

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Last Updated: Jun 26, 2026

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  • Evaluation of optical properties, including near-infrared fluorescence emission and Stokes shift.
  • Cell imaging experiments using PC12 cells to assess selectivity and cytotoxicity.

    • Main Results:

    • BQ-1 demonstrated high affinity (KD = 48.81 nM) and sensitivity (LOD = 52 nM) for Aβ42 aggregates.
    • BQ-1 exhibited a high signal-to-noise ratio (189.5-fold) and favorable near-infrared fluorescence emission (λex/λem = 612/669 nm).
    • Cell imaging confirmed BQ-1's ability to selectively label Aβ42 aggregates with low cytotoxicity.

    Conclusions:

    • BQ-1 is a high-performance near-infrared fluorescent probe suitable for targeting Aβ42 aggregates.
    • BQ-1 shows significant potential as a tool for early pathological imaging diagnosis of Alzheimer's disease.