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Related Concept Videos

Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
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Yellow Fever01:18

Yellow Fever

Yellow fever is a viral hemorrhagic disease caused by the yellow fever virus (YFV), a member of the Flaviviridae family. It is transmitted primarily by Aedes and Haemagogus mosquitoes in tropical and subtropical regions of Africa and South America. After transmission through a mosquito bite, the virus initially replicates in skin-resident immune cells such as dendritic cells and macrophages. These cells then migrate to the lymph nodes, where viral replication increases, eventually leading to...

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Correction: Fukushima et al. Long-Term Immunogenicity of Rabies Pre-Exposure Prophylaxis in Japanese Adult Travelers: Comparison of Dosing Regimens. <i>Vaccines</i> 2025, <i>13</i>, 1169.

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Related Experiment Video

Updated: Jun 26, 2026

Using Reverse Genetics to Manipulate the NSs Gene of the Rift Valley Fever Virus MP-12 Strain to Improve Vaccine Safety and Efficacy
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Using Reverse Genetics to Manipulate the NSs Gene of the Rift Valley Fever Virus MP-12 Strain to Improve Vaccine Safety and Efficacy

Published on: November 1, 2011

Neutralizing Antibodies Against Rift Valley Fever Virus: Current Status and Advances.

Binjie Wu1, Yuhan Sun1, Yang Wang1

  • 1Student Brigade, School of Basic Medicine, Air Force Medical University: Fourth Military Medical University, Xi'an 710032, China.

Vaccines
|June 25, 2026
PubMed
Summary
This summary is machine-generated.

Potent neutralizing antibodies (NAbs) targeting Rift Valley fever virus (RVFV) glycoproteins show promise for treating RVFV infections. Further research is needed to overcome translational challenges for clinical application.

Keywords:
Rift Valley fever virusantibody therapeuticsenvelope glycoprotein Gn and Gcimmune escapeneutralizing antibodyviral entryzoonotic disease

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Last Updated: Jun 26, 2026

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An Improved and High Throughput Respiratory Syncytial Virus (RSV) Micro-neutralization Assay
09:14

An Improved and High Throughput Respiratory Syncytial Virus (RSV) Micro-neutralization Assay

Published on: January 26, 2019

Area of Science:

  • Virology
  • Immunology
  • Infectious Diseases

Background:

  • Rift Valley fever virus (RVFV) is a mosquito-borne zoonotic pathogen causing epidemics in Africa and the Arabian Peninsula.
  • RVFV poses significant threats to public health and livestock, causing high mortality in ruminants and severe illness in humans.
  • There is an urgent need for licensed human vaccines and specific antiviral therapeutics against RVFV.

Purpose of the Study:

  • To systematically review and synthesize data on RVFV neutralizing antibodies (NAbs).
  • To analyze antibody sources, epitope specificity, neutralizing potency, protective efficacy, and mechanisms of action.

Main Methods:

  • Systematic literature review of peer-reviewed studies on RVFV NAbs.
  • Data extraction and synthesis on antibody characteristics and efficacy.
  • Analysis of molecular mechanisms of neutralization.

Main Results:

  • Potent NAbs have been identified from various immunized animal models and convalescent patients.
  • These NAbs primarily target the Gn and Gc envelope glycoproteins of RVFV.
  • Lead NAb candidates demonstrate high neutralization potency and provide robust protection in preclinical models, with enhanced efficacy through bispecific and combination strategies.

Conclusions:

  • Significant progress has been made in understanding RVFV NAb epitope landscape and neutralization mechanisms, identifying promising clinical candidates.
  • Remaining challenges include viral immune escape, antibody thermostability, and the necessity for rigorous preclinical evaluation.
  • Future research should focus on structure-guided engineering, rational antibody combinations, and testing in clinically relevant animal models.