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Updated: Jun 26, 2026

Closure of a Patent Foramen Ovale (PFO): An Intervention Sequence
Published on: December 23, 2022
Percutaneous Closure of a Giant Secundum Atrial Septal Defect Using 2 Sutured Occluders
Arturo Giacaman1, Georgi Fram1, Pedro Engel1
1Structural Heart Disease Center, Henry Ford Hospital, Detroit, Michigan, USA.
Background:
Giant secundum atrial septal defects (ASDs) are generally considered unsuitable for transcatheter closure and often require surgical repair. Innovative percutaneous strategies may provide an alternative in prohibitive-risk patients.
Case Summary:
A 75-year-old man with a giant secundum ASD (64.5 × 38.8 mm), severe mitral and tricuspid regurgitation, pulmonary hypertension, atrial fibrillation, cirrhosis, and chronic kidney disease was deemed inoperable. After staged mitral and tricuspid transcatheter edge-to-edge repair, the ASD was successfully closed using two 38-mm septal occluder devices sutured together ex vivo and simultaneously deployed, resulting in stable device position without residual shunt.
Discussion:
This case demonstrates a novel percutaneous strategy for closure of exceptionally large ASDs exceeding currently available occluder size limits.
Take-Home Message:
Percutaneous closure of giant ASDs may be feasible in selected prohibitive-risk patients using coupled occluder devices.

