Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Adsorption Isotherms II01:25

Adsorption Isotherms II

Brunauer, Emmett, and Teller (BET) introduced a theory in 1938 that modified Langmuir's assumptions to explain multilayer physical adsorption. This theory is applicable to Type II isotherms and provides a more realistic picture of adsorption processes. The BET theory assumes a uniform solid surface with localized adsorption sites, where adsorption at one site doesn't affect adsorption at neighboring sites. This theory also allows for the possibility of additional molecules being adsorbed on top...
Debye–Huckel–Onsager Conductance Equation01:28

Debye–Huckel–Onsager Conductance Equation

The Debye-Hückel-Onsager equation is a cornerstone of physical chemistry, providing a method to determine the molar conductance (Λm) and molar conductance at infinite dilution (Λ°m) for uni-univalent electrolytes.Uni-univalent electrolytes are electrolytes that dissociate in solution to produce one cation with a +1 charge and one anion with a –1 charge per formula unit.This equation addresses two crucial phenomena: the asymmetry effect and the electrophoretic effect. According to this equation,...
Adsorption Isotherms I01:29

Adsorption Isotherms I

Adsorption isotherms are mathematical models that describe how molecules in a gas or liquid phase interact with surfaces. Two of the most common isotherm models are the Langmuir and Freundlich isotherms, which relate to Type I monolayer chemisorption. The Langmuir model is based on four key assumptions:• Adsorption cannot exceed monolayer coverage.• All surface sites are equivalent.• Molecules adsorb only at vacant sites.• There are no interactions between adsorbed molecules.Consider the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Highly Sensitive Measurement of the Refractive Index of Mesoporous Hollow Silica Microcapsules Using Whispering Gallery Mode Resonances.

Sensors (Basel, Switzerland)·2026
Same author

Detection of SARS-CoV-2 N protein using AgNPs-modified aligned silicon nanowires BioSERS chip.

RSC advances·2024
Same journal

In Vitro and In Silico Assessment of Anticancer Activity of Venom-Derived and Biomimetic Neurotransmitter Inhibitor Pentapeptides.

Cell biochemistry and biophysics·2026
Same journal

Green Fabrication and Characterization of Copper Oxide Nanoparticles Using C. Gigantea Leaf Extract and Their ROS-Mediated Anticancer Activity Against A549 Lung Cancer Cells.

Cell biochemistry and biophysics·2026
Same journal

From Isoprene Units to Polyprenols and Dolichols: 70 Years of Polyisoprenoid Biosynthesis Research.

Cell biochemistry and biophysics·2026
Same journal

Therapeutic Insights into the Hepatoprotective Effect of Strobilanthes callosa.

Cell biochemistry and biophysics·2026
Same journal

The Dual Role of TGF-β and Hypoxia on MMP14-Mediated Invasion in PC3 Cells.

Cell biochemistry and biophysics·2026
Same journal

Microalgae-Mediated Synthesis of Gold Nanoparticles from Indonesian Chlorella vulgaris InaCC M205 with Potential Anticancer Properties for Biomedical Application.

Cell biochemistry and biophysics·2026
See all related articles

Related Experiment Video

Updated: Jun 26, 2026

Optimized Fabrication Procedure for High-Quality Graphene-based Moiré Superlattice Devices
11:24

Optimized Fabrication Procedure for High-Quality Graphene-based Moiré Superlattice Devices

Published on: July 11, 2025

Adsorption-driven Graphene Oxide SPR Biointerfaces: Coupled Thermodynamic, Kinetic, and Optical Modeling with

Sadok Kouz1

  • 1Laboratoire Lumière Matière et Interfaces (LUMIN), UMR 9024, Ecole Normale Supérieure Paris-Saclay, CentraleSupélec, CNRS, Université Paris-Saclay, 4 avenue des Sciences, 91190, Gif-sur-Yvette, France. sadok.kouz@ens-paris-saclay.fr.

Cell Biochemistry and Biophysics
|June 25, 2026
PubMed
Summary
This summary is machine-generated.

This study develops a theoretical model for graphene oxide (GO)-functionalized surface plasmon resonance (SPR) biointerfaces, linking molecular adsorption to optical signals. The framework optimizes GO-SPR sensor performance and predicts detection limits for biosensing applications.

Keywords:
Adsorption-driven sensingBinding kineticsGraphene oxide biointerfaceLangmuir–Hill adsorptionSurface plasmon resonanceTransfer matrix modeling

More Related Videos

Fabrication of Gate-tunable Graphene Devices for Scanning Tunneling Microscopy Studies with Coulomb Impurities
11:42

Fabrication of Gate-tunable Graphene Devices for Scanning Tunneling Microscopy Studies with Coulomb Impurities

Published on: July 24, 2015

Atomic Layer Deposition of Vanadium Dioxide and a Temperature-dependent Optical Model
11:10

Atomic Layer Deposition of Vanadium Dioxide and a Temperature-dependent Optical Model

Published on: May 23, 2018

Related Experiment Videos

Last Updated: Jun 26, 2026

Optimized Fabrication Procedure for High-Quality Graphene-based Moiré Superlattice Devices
11:24

Optimized Fabrication Procedure for High-Quality Graphene-based Moiré Superlattice Devices

Published on: July 11, 2025

Fabrication of Gate-tunable Graphene Devices for Scanning Tunneling Microscopy Studies with Coulomb Impurities
11:42

Fabrication of Gate-tunable Graphene Devices for Scanning Tunneling Microscopy Studies with Coulomb Impurities

Published on: July 24, 2015

Atomic Layer Deposition of Vanadium Dioxide and a Temperature-dependent Optical Model
11:10

Atomic Layer Deposition of Vanadium Dioxide and a Temperature-dependent Optical Model

Published on: May 23, 2018

Area of Science:

  • Biophysics
  • Materials Science
  • Nanotechnology

Background:

  • Surface Plasmon Resonance (SPR) biosensors are crucial for label-free biomolecular detection.
  • Graphene Oxide (GO) functionalization enhances SPR sensitivity and stability.
  • Theoretical modeling is needed to optimize GO-SPR biointerface performance.

Purpose of the Study:

  • To develop a theoretical framework for adsorption-driven GO-functionalized SPR biointerfaces.
  • To link molecular adsorption parameters (concentration, kinetics, thermodynamics) to SPR optical response.
  • To optimize GO-SPR sensor design and predict performance metrics.

Main Methods:

  • Coupling transfer-matrix optical modeling with generalized Langmuir-Hill adsorption formalism.
  • Simulating angular interrogation at 633 nm for a prism/TiW/Au/GO multilayer structure.
  • Incorporating temperature dependence via van't Hoff treatment and time-dependence via first-order kinetics.

Main Results:

  • Optimized effective thicknesses for Au, TiW, and GO layers were identified.
  • Model predicts resonance shifts, effective biolayer thickness, and refractive-index sensitivity.
  • Estimated limit of detection is ~0.027 μM with optimal angular resolution, dependent on angular noise.

Conclusions:

  • The developed framework provides a mechanism-aware computational tool for GO-SPR biointerfaces.
  • It connects adsorption thermodynamics and kinetics to SPR optical signals.
  • The model highlights effective-parameter limits and guides experimental validation for biosensor development.