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Updated: Jun 26, 2026
08:45
Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
Published on: December 28, 2017
Unraveling clade-specific differences in Candida auris: evolution, adaptation, and pathogenicity.
Preeti Sharma1, Vinay Kumar Bari2, Ritu Pasrija3
1Department of Biochemistry, Maharshi Dayanand University, Rohtak, Haryana, 124001, India.
Summary
Candida auris is a critical fungal pathogen with six distinct genomic clades, each posing unique clinical risks and resistance patterns. A clade-aware approach integrating genomic surveillance is crucial for effective management and containment.
Area of Science:
- * Medical Mycology
- * Infectious Diseases
- * Genomics
Background:
- * Candida auris (C. auris) emerged in 2009 and is now a global health threat.
- * C. auris exhibits a complex population structure with six distinct genomic clades.
- * Each clade displays unique evolutionary paths, traits, and clinical risks.
Purpose of the Study:
- * To systematically synthesize literature on C. auris comparative genomics, clade-specific virulence, and diagnostic accuracy.
- * To identify patterns in clade divergence and antifungal resistance.
- * To propose a "clade-aware" framework for public health management.
Main Methods:
- * Systematic literature review of PubMed, Scopus, and Google Scholar (2009-2026).
- * Analysis of 64 studies focusing on comparative genomics and clade characteristics.
- * Identification of diagnostic platform limitations for C. auris clades.
Main Results:
- * C. auris is a diverse pathogen, not a monolithic threat.
- * Clades I and IV show highest risk due to hyper-virulence and multi-drug resistance (MDR).
- * Diagnostic platforms misidentify Clades II and III, hindering accurate detection.
Conclusions:
- * A "clade-aware" framework is proposed for public health.
- * Genomic surveillance and clade-specific infection control are vital for management.
- * Targeted containment strategies based on clade characteristics are essential for precision public health.
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