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Updated: Jun 26, 2026

Mouse Model of Metabolic Dysfunction-Associated Steatotic Liver Disease with Fibrosis
Published on: July 18, 2025
Cost-Effectiveness of Pharmacologic Therapies for Metabolic Dysfunction-Associated Steatohepatitis With Significant
Ali A Abdeen1,2, Turgay Ayer1, Aanan Biswas1
1Department of Industrial and Systems Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA.
Aims:
The approval of new pharmacotherapies for metabolic dysfunction-associated steatohepatitis (MASH) presents a critical need for value assessment. We evaluated the cost-effectiveness of resmetirom, semaglutide and tirzepatide for U.S. adults with MASH and F2-F3 fibrosis.
Materials And Methods:
We developed a Markov cohort model with a lifetime horizon from the perspective of a U.S. healthcare payer. The model simulated biopsy-confirmed patients with MASH progressing through liver-specific health states. Efficacy inputs for fibrosis regression and MASH resolution were obtained from a Bayesian network meta-analysis. Each pharmacotherapy was compared individually against standard of care; a formal sequential incremental analysis across active therapies was not performed. Cost-effectiveness was assessed against the standard of care using a $100 000/QALY willingness-to-pay threshold.
Results:
In the base-case analysis, tirzepatide had the largest QALY gain and the lowest incremental cost relative to standard of care, yielding an incremental cost-effectiveness ratio of ($42 705/QALY). Semaglutide was also cost-effective (ICER: $80 076/QALY). Resmetirom (ICER: $273 445/QALY) exceeded the WTP threshold. Drug price was the most influential parameter in sensitivity analyses; probabilistic sensitivity analysis showed a 99.5% probability of cost-effectiveness for tirzepatide and 89.8% for semaglutide at $100 000/QALY.
Conclusions:
At current U.S. prices, tirzepatide and semaglutide are cost-effective for MASH with F2-F3 fibrosis, while resmetirom is not. The tirzepatide finding should be interpreted with caution, given that it is not yet FDA-approved for MASH and its effect estimate is based on a network meta-analysis of a phase 2 trial. Payer coverage and equitable access to MASH therapies require value-based pricing strategies.
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