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Related Experiment Video

Updated: Jun 26, 2026

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

circMAN1A2 as an Isoform-Resolved Circular RNA Hub in Cancer.

Hanyu Shang^1,2, Hui Wang¹, Yonghang Xu¹

¹School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.

|June 25, 2026

Summary

Circular RNAs (circRNAs) like circMAN1A2 are key cancer regulators. This review details circMAN1A2

Keywords:

RNA‐binding proteins RNA–RNA interaction alternative circularization antisense oligonucleotide back‐splice junction circMAN1A2 circular RNA competing endogenous RNA tumor microenvironment

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Last Updated: Jun 26, 2026

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

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Published on: October 21, 2022

Identification of Circular RNAs using RNA Sequencing

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

Use of Alu Element Containing Minigenes to Analyze Circular RNAs

Use of Alu Element Containing Minigenes to Analyze Circular RNAs

Published on: March 10, 2020

Area of Science:

Molecular Biology
Cancer Research
RNA Biology

Background:

Circular RNAs (circRNAs) are stable, specific RNA molecules involved in cancer regulation.
circMAN1A2, derived from the MAN1A2 gene, is frequently altered in various cancers.
Understanding circMAN1A2's diverse roles is crucial for cancer biomarker and therapeutic development.

Purpose of the Study:

To comprehensively review the biology of circMAN1A2.
To evaluate the mechanistic and translational significance of circMAN1A2 in cancer.
To explore circMAN1A2's potential as a biomarker and therapeutic target.

Main Methods:

Literature review integrating current knowledge on circMAN1A2.
Analysis of circMAN1A2 isoforms, biogenesis, and interactome.
Evaluation of cancer-type-specific phenotypes associated with circMAN1A2.

Main Results:

circMAN1A2 acts as an isoform-resolved RNA hub with diverse functions beyond miRNA sponging.
It engages in protein binding, proteostasis regulation, and direct circRNA-mRNA interactions.
circMAN1A2 exhibits context-dependent effects, promoting oncogenesis in some cancers while suppressing glioblastoma.

Conclusions:

circMAN1A2's complex roles and isoform diversity necessitate isoform-specific investigation.
Potential for circMAN1A2-based biomarkers and therapeutics, including oligonucleotide-based strategies.
Standardization of isoform-specific analysis is vital for clinical translation.