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Updated: Jun 26, 2026

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
Published on: June 15, 2019
When Sepsis Kills: A Fatal Cascade of Invasive Group A Streptococcal Sepsis
Presentation:
A previously healthy 22-year-old woman presented with right groin pain, unilateral leg swelling, and dyspnoea following recent infection and minor trauma. She was hypotensive and tachycardic with a painful, mottled limb and oxygen saturations of 91%.
Diagnosis:
Investigations demonstrated lactic acidosis, coagulopathy, pulmonary emboli, visceral infarcts, and necrotising soft-tissue infection. Cultures confirmed Streptococcus pyogenes.
Treatment:
Despite antibiotics, emergency surgery, and advanced life support, the patient died of multiorgan failure.
Discussion:
iGAS infection can mimic thromboembolic disease and requires urgent recognition.
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