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Histone lactylation-driven intratumoral IGFBP2+ NK cells promote tumor immune evasion

Xuben Wang1, Zhuanghao Hou2, Qikai Sun3

  • 1State Key Laboratory of Immune Response and Immunotherapy, Institute of Immunology, School of Basic Medical Sciences, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, Hefei National Laboratory for Physical Sciences at Microscale, University of Science and Technology of China, Hefei 230027, China.

Cell Reports
|June 25, 2026
PubMed

Keywords:
CP: cancerCP: immunologyhistone lactylationimmune checkpoint-targeted therapyinsulin-like growth factor binding protein 2liver cancernatural killer cell

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