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Association between depression and cardiometabolic multimorbidity: A protocol for a systematic review and

Myo Zin Oo1, Soe Sandi Tint2,3, Somdeth Bodhisane4

  • 1Research Institute for Health Sciences, Chiang Mai University, Chiang Mai, Thailand.

Plos One
|June 25, 2026
PubMed

Insights

This study synthesizes evidence on depression and cardiometabolic multimorbidity (CMM). It aims to understand the link between depression and CMM and its prevalence in adults with depression.

Area of Science:

  • Public Health
  • Epidemiology
  • Mental Health Research

Background:

  • Cardiometabolic multimorbidity (CMM) is a growing public health concern.
  • The association between depression and CMM requires comprehensive synthesis.
  • Understanding this link is crucial for managing patient morbidity and mortality.

Purpose of the Study:

  • To systematically review and meta-analyze observational data on depression and CMM.
  • To estimate the prevalence of CMM in adults experiencing depression.
  • To provide evidence for improved clinical practice and public health strategies.

Main Methods:

  • Systematic search of PubMed, Embase, and Scopus databases.
  • Inclusion of observational studies (cohort, case-control, cross-sectional) in adults.
  • Meta-analysis of adjusted association estimates and pooled prevalence of CMM.

Main Results:

  • The review will synthesize observational evidence on the depression-CMM association.
  • Prevalence of CMM among adults with depression will be estimated.
  • Subgroup and sensitivity analyses will explore heterogeneity.

Conclusions:

  • This review will enhance understanding of the depression-CMM relationship.
  • Findings are expected to inform future research and clinical guidelines.
  • The study will contribute to developing targeted public health interventions.
Abstract

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