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Related Experiment Video

Updated: Jun 27, 2026

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Published on: November 12, 2015

Laser vision correction (LASIK, PRK, SMILE) with simultaneous accelerated corneal crosslinking.

Li Lim^1,2,3

¹Singapore National Eye Centre.

Current Opinion in Ophthalmology

|June 25, 2026

Summary

Combining laser vision correction with corneal crosslinking (CXL) like LASIK Xtra, PRK Xtra, and SMILE Xtra is safe and effective for myopia. These combined procedures show no cases of keratectasia in susceptible eyes, offering biomechanical advantages.

Keywords:

accelerated cross-linking laser in-situ keratomileusis photorefractive keratectomy refractive surgery small-incision lenticule extraction

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Area of Science:

Ophthalmology
Corneal Surgery
Vision Correction

Background:

Corneal refractive surgery aims to correct refractive errors.
Corneal crosslinking (CXL) strengthens the cornea.
Combining these procedures may enhance outcomes.

Purpose of the Study:

To review recent literature (2020-2025) on corneal refractive surgery combined with simultaneous CXL.
To determine the safety and efficacy of LASIK Xtra, PRK Xtra, and SMILE Xtra.

Main Methods:

Comprehensive literature search of PubMed, PubMed Central, and MEDLINE up to December 2025.
Inclusion of English articles on clinical outcomes of LASIK Xtra, PRK Xtra, and SMILE Xtra (2020-2025).
Evaluation of efficacy and safety indices.

Main Results:

10 studies on LASIK Xtra, 3 on PRK Xtra, and 8 on SMILE Xtra were identified.
Refractive surgery with simultaneous CXL shows comparable refractive and keratometric stability to surgery alone.
No postoperative keratectasia reported in susceptible eyes; biomechanical advantages observed.

Conclusions:

Simultaneous accelerated CXL and laser vision correction are safe and effective for myopia treatment.
These combined procedures in susceptible eyes show no keratectasia, indicating biomechanical benefits.