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Published on: March 21, 2021

Use of the Online Portal "Embryotox" in Routine Health Care: Mixed Methods Study.

Marlies Onken¹, Evelin Beck¹, Martina Breuning²

¹Charité - University Medical Center Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Clinical Pharmacology and Toxicology, Embryotox Center of Clinical Teratology and Drug Safety in Pregnancy, Augustenburger Platz 1, 13353, Berlin, Germany, 49 030 450 525 702, 49 030 450 7525729.

Journal of Medical Internet Research

|June 25, 2026

Summary

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Teratogenicity

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...

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This summary is machine-generated.

The Embryotox website provides trusted, understandable drug safety information for pregnant and breastfeeding women. Its use facilitates informed decision-making for patients and healthcare professionals, improving drug safety.

Area of Science:

Pharmacovigilance
Reproductive Toxicology
Evidence-Based Medicine

Background:

Embryotox, an open-access portal since 2008, offers evidence-based drug safety information for pregnancy and breastfeeding.
Maintained by the Embryotox Center at Charité - Universitätsmedizin Berlin, it provides fact sheets on approximately 400 drugs.
The website experienced over 5 million accesses in 2024, highlighting its significance.

Purpose of the Study:

To evaluate the user demographics, usage patterns, and needs fulfillment of the Embryotox website.
To assess the impact of Embryotox information on users' risk perception and treatment decisions.
To understand user trust and the functional utility of the website across different stakeholder groups.

Main Methods:

A sequential mixed-methods design combining online questionnaires and semistructured phone interviews.

Keywords:

breastfeeding consumer health information drug safety online health information pregnancy risk assessment shared decision-making

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Data collection involved 14,562 users for Questionnaire 1 and 793 users for Questionnaire 2.

Analysis included descriptive statistics for quantitative data and content analysis for qualitative insights.

Main Results:

High comprehensibility ratings (8.80-9.39) and trust in Embryotox information were reported by users.
Over 66% of users adjusted their risk perception, and 22% considered changing drug treatment after using the fact sheets.
Benefits included facilitated decision-making and increased confidence, particularly for physicians and patients.

Conclusions:

Embryotox fact sheets are perceived as comprehensible and trustworthy, effectively supporting decision-making.
The website is successfully utilized in routine healthcare, enhancing drug safety for pregnant and breastfeeding women.
Embryotox plays a crucial role in improving therapeutic decisions during pregnancy and lactation.