Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Isolation of postnatal human neural stem cells.

bioRxiv : the preprint server for biology·2026
Same author

Cerebrovascular vulnerability and fibrosis in human brain aneurysms.

Nature neuroscience·2026
Same author

Histone methyltransferase NSD1 maintains Egr1 expression to orchestrate primary/reactionary dentinogenesis.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026
Same author

Optogenetic WNT signaling drives germ layer self-organization in a human gastruloid model.

bioRxiv : the preprint server for biology·2026
Same author

Dental pulp stem cell-derived exosomes attenuate psoriatic inflammation by restoring epithelial redox homeostasis via a miR-1246/miR-17-3p-GPX2-NF-κB axis.

Stem cell research & therapy·2026
Same author

Author Correction: Multidimensional profiling of heterogeneity in supratentorial ependymomas.

Nature·2026
Same journal

Temporal trajectories underlying adult neuronal diversity.

Current opinion in genetics & development·2026
Same journal

Transcription regulation of cell fate plasticity - from embryonic development to tissue regeneration.

Current opinion in genetics & development·2026
Same journal

Shared molecular and cellular programs during regeneration of glandular epithelia.

Current opinion in genetics & development·2026
Same journal

Cis-regulatory strategies in developmental patterning.

Current opinion in genetics & development·2026
Same journal

GABAergic neuron fate specification and lineage allocation: from development to disorder.

Current opinion in genetics & development·2026
Same journal

Active processes shape and move the genome and nucleoplasm.

Current opinion in genetics & development·2026
See all related articles

Related Experiment Video

Updated: Jun 27, 2026

Lineage Tracing and Clonal Analysis in Developing Cerebral Cortex Using Mosaic Analysis with Double Markers (MADM)
09:25

Lineage Tracing and Clonal Analysis in Developing Cerebral Cortex Using Mosaic Analysis with Double Markers (MADM)

Published on: May 8, 2020

Lineage tracing in human cortical development.

Guohua Yuan1, Marilyn Steyert1, Tomasz J Nowakowski2

  • 1Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.

Current Opinion in Genetics & Development
|June 25, 2026
PubMed
Summary
This summary is machine-generated.

Understanding how progenitor cell lineage relationships shape human brain development is key. New lineage tracing methods reveal distinct human cortical development, offering insights into neurodevelopmental disorders.

More Related Videos

Live Imaging of Primary Cerebral Cortex Cells Using a 2D Culture System
10:12

Live Imaging of Primary Cerebral Cortex Cells Using a 2D Culture System

Published on: August 9, 2017

Lineage Tracing of Inducible Fluorescently-Labeled Stem Cells in the Adult Mouse Brain
09:44

Lineage Tracing of Inducible Fluorescently-Labeled Stem Cells in the Adult Mouse Brain

Published on: May 20, 2022

Related Experiment Videos

Last Updated: Jun 27, 2026

Lineage Tracing and Clonal Analysis in Developing Cerebral Cortex Using Mosaic Analysis with Double Markers (MADM)
09:25

Lineage Tracing and Clonal Analysis in Developing Cerebral Cortex Using Mosaic Analysis with Double Markers (MADM)

Published on: May 8, 2020

Live Imaging of Primary Cerebral Cortex Cells Using a 2D Culture System
10:12

Live Imaging of Primary Cerebral Cortex Cells Using a 2D Culture System

Published on: August 9, 2017

Lineage Tracing of Inducible Fluorescently-Labeled Stem Cells in the Adult Mouse Brain
09:44

Lineage Tracing of Inducible Fluorescently-Labeled Stem Cells in the Adult Mouse Brain

Published on: May 20, 2022

Area of Science:

  • Developmental Neuroscience
  • Genetics
  • Cell Biology

Background:

  • Cellular diversity and organization of the human cortex are shaped by progenitor lineage relationships.
  • Lineage tracing captures cellular history to understand developmental trajectories and progenitor fate potential.

Purpose of the Study:

  • To review advances in lineage tracing techniques for studying human cortical development.
  • To highlight distinct features of human cortical progenitor behavior compared to rodent models.
  • To explore the role of lineage dynamics in neurodevelopmental disorders.

Main Methods:

  • Prospective viral barcoding
  • CRISPR-based evolvable lineage recording
  • Retrospective inference from endogenous somatic mutations

Main Results:

  • Human cortical progenitors show expanded fate potential and prolonged temporal control.
  • Lineage output is temporally regulated and spatially patterned.
  • Human cortical development exhibits distinct features compared to rodent models.

Conclusions:

  • Lineage tracing is crucial for understanding human cortical development and cellular diversity.
  • Disrupted lineage dynamics may underlie neurodevelopmental disorders.
  • Recognizing lineage dynamics is essential for linking developmental ancestry to disease vulnerability.