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Updated: Jun 27, 2026

High-Temperature and High-Pressure In situ Magic Angle Spinning Nuclear Magnetic Resonance Spectroscopy
Published on: October 9, 2020
Research advances in in situ electrochemistry-nuclear magnetic resonance technology
Xiaoping Zhang1, Rongrong Xie1, Muyuan Li1
1Hainan International Joint Research Center of Marine Advanced Photoelectric Functional Materials, Key Laboratory of Laser Technology and Optoelectronic Functional Materials of Hainan Province, Key Laboratory of Functional Materials and Photoelectrochemistry of Haikou, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, 571158, China.
Abstract:
Electrochemistry-nuclear magnetic resonance (EC-NMR) technology enables real-time, in situ, and non-destructive molecular-level monitoring of electrochemical adsorption, catalytic processes, and redox reactions. It is uniquely capable of capturing short-lived, low-concentration reaction intermediates that are inaccessible to conventional ex-situ characterization methods, providing definitive molecular evidence for elucidating electrochemical reaction mechanisms and structure-activity relationships. Despite its great potential in electrocatalysis and energy material research, the inherent incompatibility between electrochemical operation and NMR detection severely restricts the further development and practical application of in-situ EC-NMR technology. Compared with existing review studies that only summarize scattered technical progress and individual applications, this review systematically and comprehensively sorts out the core scientific bottlenecks of liquid-phase in situ EC-NMR, the iterative evolution of electrochemical coupling devices, and key compatibility optimization strategies for NMR spectroscopy detection. Meanwhile, we emphatically summarize its advanced applications in organic molecular electrocatalytic redox reactions and battery energy storage systems, and briefly supplement the latest research advances of emerging solid-state in-situ EC-NMR technology. On this basis, we further clarify the key technical challenges restricting current system performance and prospect the core breakthrough directions and future development trends of in-situ EC-NMR technology from both technical innovation and multi-field application expansion perspectives. This review aims to provide targeted reference and forward-looking guidance for the further optimization of coupled devices, performance improvement, and diversified industrial application of in-situ EC-NMR technology.
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