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Updated: Jun 27, 2026
05:49
Modeling the Effects of Hemodynamic Stress on Circulating Tumor Cells using a Syringe and Needle
Published on: April 27, 2021
Intratumoral B cells under stress
1Department of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel.
Cancer Cell
|June 25, 2026
Abstract:
In this issue of Cancer Cell, Bashir et al. show that stress-induced corticosterone suppresses germinal center B cell responses and impairs anti-tumor immunity. Their study identifies gut microbiota-derived phage DNA as a key trigger of TLR9 activation and corticosterone secretion by cancer-associated fibroblasts, revealing an intricate bacteria-driven immune-suppression mechanism.
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