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Related Experiment Video

Updated: Jun 27, 2026

Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals

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Published on: March 30, 2017

Development and evaluation of thymol/PVP solid dispersion: comparative physicochemical properties and bronchodilation

Bader Alsulays¹, Fahad S Almutib¹, Najeeb U Rehman²

¹Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, AlKharj 11942, Saudi Arabia.

Biomedical Physics & Engineering Express

|June 25, 2026

Summary

This study enhanced thymol

Keywords:

PVP asthma bronchodilation release thymol

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Last Updated: Jun 27, 2026

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Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

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Published on: April 6, 2017

Area of Science:

Pharmacology and Pharmaceutical Sciences
Natural Products Chemistry

Background:

Asthma is a chronic respiratory disease involving airway inflammation.
Thymol, a natural monoterpene, possesses bronchodilatory properties.
Improving thymol's physicochemical properties can enhance its therapeutic potential.

Purpose of the Study:

To formulate a thymol-polyvinylpyrrolidone (PVP) solid dispersion.
To evaluate the physicochemical properties and dissolution of the thymol-PVP formulation.
To assess the bronchodilatory efficacy of the enhanced thymol formulation.

Main Methods:

Preparation of a thymol-PVP solid dispersion.
Characterization using Differential Scanning Calorimetry (DSC) and Powder X-ray Diffraction (PXRD).
In vitro dissolution studies and in vivo tracheal relaxation assays.

Main Results:

The thymol-PVP solid dispersion successfully transformed crystalline thymol into an amorphous form.
Enhanced dissolution rate of thymol from the formulation compared to pure thymol.
The formulation demonstrated significantly greater tracheal relaxation than thymol alone.

Conclusions:

Formulating thymol with PVP improves its physicochemical properties, particularly dissolution.
The enhanced thymol formulation shows promising therapeutic potential for respiratory disorders like asthma.
This approach offers a viable strategy for developing improved natural product-based asthma therapies.