Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Viral Recombination00:57

Viral Recombination

Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Status of Nuclear Medicine in Nepal: Current Infrastructure, Challenges, and Future Perspectives.

World journal of nuclear medicine·2026
Same author

Spontaneous Expulsion of Rectally Inserted Tramadol Ampoules: An Unusual Case Report of Drug Concealment and Delayed Disclosure.

Case reports in surgery·2026
Same author

Ultrasound versus traditional formula for subglottic diameter-based uncuffed endotracheal tube selection in pediatric patients.

Bioinformation·2026
Same author

Three-Dimensional Reconstruction of the Sternum: a Novel Approach for Improved Surgical Oncology Outcomes.

Indian journal of surgical oncology·2026
Same author

Unusual Cause of Distress in an Intellectually Disabled Adolescent: A Reminder to Suspect Foreign Body Ingestion.

Clinical case reports·2026
Same author

Discovery of thieno[3,2-<i>c</i>]pyran-based leads for liver, lung and glioma cancer: synthesis, docking-guided optimization and apoptotic profiling.

RSC advances·2026

Related Experiment Video

Updated: Jun 27, 2026

Identification of Coding and Non-coding RNA Classes Expressed in Swine Whole Blood
09:40

Identification of Coding and Non-coding RNA Classes Expressed in Swine Whole Blood

Published on: November 28, 2018

Genome-wide transcriptome profiling in crossbred pigs after challenge with Classical Swine Fever Virus.

Ayushi Singh1, Amit Kumar1, Shivani Khanna1

  • 1Division of Animal Genetics, Indian Veterinary Research Institute, Izatnagar, Bareilly, India.

Microbial Pathogenesis
|June 25, 2026
PubMed
Summary

Classical Swine Fever Virus (CSFV) infection in pigs triggers a strong innate immune response but suppresses adaptive immunity. This dual response, involving gene expression changes, offers insights for developing CSFV vaccines and therapies.

Keywords:
Classical swine feverCytokine responseImmune responseIn-vivo challengeLAMB4 gene

More Related Videos

Nasal Wipes for Influenza A Virus Detection and Isolation from Swine
05:59

Nasal Wipes for Influenza A Virus Detection and Isolation from Swine

Published on: December 4, 2015

A Seamless Cloning Approach for Porcine Reproductive and Respiratory Syndrome Virus Expression Vector Construction
04:18

A Seamless Cloning Approach for Porcine Reproductive and Respiratory Syndrome Virus Expression Vector Construction

Published on: May 17, 2024

Related Experiment Videos

Last Updated: Jun 27, 2026

Identification of Coding and Non-coding RNA Classes Expressed in Swine Whole Blood
09:40

Identification of Coding and Non-coding RNA Classes Expressed in Swine Whole Blood

Published on: November 28, 2018

Nasal Wipes for Influenza A Virus Detection and Isolation from Swine
05:59

Nasal Wipes for Influenza A Virus Detection and Isolation from Swine

Published on: December 4, 2015

A Seamless Cloning Approach for Porcine Reproductive and Respiratory Syndrome Virus Expression Vector Construction
04:18

A Seamless Cloning Approach for Porcine Reproductive and Respiratory Syndrome Virus Expression Vector Construction

Published on: May 17, 2024

Area of Science:

  • Veterinary Immunology
  • Molecular Virology
  • Swine Health

Background:

  • Classical Swine Fever Virus (CSFV) poses a significant threat to global swine production.
  • Understanding the host's immune response is crucial for effective disease control and intervention strategies.

Purpose of the Study:

  • To comprehensively characterize the immune response, differential gene expression, and functional alterations in pigs challenged with CSFV.
  • To identify key genes and pathways involved in host defense and viral evasion.

Main Methods:

  • RNA-sequencing of whole blood samples from pigs before and after CSFV infection.
  • Analysis of differentially expressed genes (DEGs), cytokine-cytokine receptor interactions, and protein-protein interactions (PPI).
  • Pathway analysis to identify affected biological processes.

Main Results:

  • Identified 3,428 differentially expressed genes, with LAMB4 being the most prominent.
  • Observed upregulation of innate immune genes (e.g., CXCL12, CCL2) and downregulation of adaptive immune genes (e.g., CD28, SLA-DQB1).
  • Revealed a core antiviral module (e.g., MX1, ISG15) and identified transcription factors linked to immune modulation and T-cell exhaustion.

Conclusions:

  • CSFV infection induces a complex host response characterized by robust innate immunity activation and simultaneous adaptive immune suppression.
  • Findings provide critical insights into host-pathogen interactions, informing the development of novel vaccines and therapeutics against CSFV.