Related Experiment Video
Updated: Jun 27, 2026

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
Published on: January 15, 2022
Letter to the Editor on "Clinical profile and optical coherence tomography based morphological characteristics of
Faizan Ahmed1, Malik Zubair Hussain1, Asad Ali1
1Shaikh Khalifa Bin Zayed Al-Nahyan Medical College, Shaikh Zayed Postgraduate Medical Institute (SZPGMI), Lahore, Pakistan.
Background:
Sharma et al reported important findings regarding optical coherence tomography (OCT)-based morphological characteristics of coronary in-stent restenosis (ISR). However, several methodological considerations require further discussion.
Main Text:
Key limitations include the cross-sectional design, absence of comparator groups, potential selection bias due to restrictive exclusion criteria, inadequate adjustment for confounding variables, and lack of standardized OCT interpretation with inter-observer variability assessment.
Conclusion:
Addressing these issues in future studies through longitudinal designs, broader inclusion criteria, standardized OCT protocols, and robust statistical analyses may improve the validity and clinical applicability of ISR research.
Related Concept Videos
Acute Coronary Syndrome III: Diagnostic Studies
Coronary Artery Disease III: Clinical Manifestations
Coronary Artery Disease II: Pathophysiology
Coronary Artery Disease I: Introduction
Imaging Studies for Cardiovascular System V: CT
