Related Experiment Video

Updated: Jun 27, 2026

Comparative Strategies for Ubiquitination Detection in Mammalian Cell Lysates Using SMAD2/SMURF2 as a Model
09:00

Comparative Strategies for Ubiquitination Detection in Mammalian Cell Lysates Using SMAD2/SMURF2 as a Model

Published on: April 17, 2026

Ubiquitination in cardiovascular diseases: From molecular mechanisms to therapeutic targeting

Jia-Yin Wang1, Tie-Ning Zhang1, Ni Yang1

  • 1Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang 110004, China; NHC Key Laboratory of Congenital Malformation, Shengjing Hospital of China Medical University, Shenyang 110004, China.

Ageing Research Reviews
|June 25, 2026
PubMed

Insights

Aging exacerbates cardiovascular diseases (CVDs). Ubiquitination, a key protein modification, regulates cellular processes vital for heart health and is implicated in CVD development and progression.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cardiovascular Research

Background:

  • Cardiovascular diseases (CVDs) are a leading global health burden, with aging as a significant risk factor.
  • Ubiquitination, a reversible posttranslational modification, dynamically regulates protein function, impacting cellular processes crucial for cardiovascular homeostasis.
  • Dysregulation of ubiquitination pathways is increasingly recognized in the initiation and progression of various cardiovascular conditions.

Purpose of the Study:

  • To provide a comprehensive review of ubiquitination's components and molecular mechanisms in cardiovascular diseases.
  • To elucidate the role of aging in cardiovascular disease and its intricate regulation by ubiquitination.
  • To highlight common regulatory pathways and discuss emerging therapeutic strategies targeting ubiquitination for CVDs.

Main Methods:

  • Literature review of ubiquitination pathways and their involvement in cardiovascular pathology.
  • Analysis of the interplay between aging, ubiquitination, and cardiovascular disease development.
  • Synthesis of current research on ubiquitination-targeted therapies for cardiovascular conditions.

Main Results:

  • Ubiquitination, orchestrated by E1, E2, E3 enzymes and deubiquitinases (DUBs), is vital for cardiovascular homeostasis.
  • Age-related dysregulation of ubiquitination contributes significantly to the pathogenesis of cardiovascular diseases.
  • Specific ubiquitination pathways are common underlying mechanisms in diverse cardiovascular conditions.

Conclusions:

  • Ubiquitination plays a critical role in cardiovascular health and disease, particularly in the context of aging.
  • Targeting ubiquitination pathways, including ubiquitin ligases and DUBs, offers promising therapeutic avenues for CVDs.
  • Further research into ubiquitination-mediated cardiovascular pathology is essential for developing novel, effective treatments.

Keywords:
Cardiovascular diseasesDUBUbiquitinasesUbiquitination

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