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A validation-driven training controller for cross-lingual biomedical NER via reinforcement learning-based adaptive
1School of Electronic and Electrical Engineering, Shanghai University of Engineering Science, Shanghai, 201620, China.
Journal of Biomedical Informatics
|June 25, 2026
Summary
RouteB-v4 enhances cross-lingual biomedical named entity recognition (BioNER) in low-resource settings. This validation-driven controller improves model robustness and performance on minority entity types without altering the backbone architecture.
Area of Science:
- Computational linguistics
- Bioinformatics
- Natural Language Processing
Background:
- Cross-lingual biomedical named entity recognition (BioNER) faces challenges in low-resource scenarios.
- Scarce annotations, diverse corpora, and imbalanced labels (dominated by the 'O' class) hinder performance.
- Existing methods often require backbone modifications or struggle with instability.
Purpose of the Study:
- To improve the robustness of BioNER fine-tuning in low-resource settings.
- To develop a method that enhances performance without altering the underlying model architecture.
- To address label imbalance and distribution shift issues in BioNER.
Main Methods:
- Propose RouteB-v4, a validation-driven training controller.
- Adaptively reweights token-level loss using entity-level feedback from validation data.
- Employs conservative, bounded updates to loss weights and regulates the 'O' label weight to ensure stability.
- Designed as a drop-in module for standard token-classification pipelines.
Main Results:
- RouteB-v4 demonstrates stable span-level F1 improvements over various baselines in English-Spanish transfer settings and Spanish datasets.
- Achieves clearer gains on minority entity types and enhances external generalization.
- Reaches 0.868 F1 on PharmaCoNER and improves CANTEMIST generalization using XLM-R within a fixed training budget.
- Performance advantage is largely retained even when controller feedback is separated from checkpoint selection.
Conclusions:
- Validation-driven adaptive loss control effectively enhances BioNER robustness.
- The proposed method successfully tackles label imbalance and distribution shift without backbone modification.
- RouteB-v4 offers a practical solution for improving cross-lingual BioNER in challenging low-resource environments.
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