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Published on: July 12, 2018
A Brief Overview of Colitis Cystica Profunda and Potential Animal Models.
Alfonso S Gozalo1, William R Elkins1
1Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland.
Summary
Colitis cystica profunda (CCP) is a rare benign lesion that can mimic cancer. This review discusses CCP in humans and animals, exploring its causes and potential animal models for research.
Area of Science:
- Gastroenterology
- Pathology
- Veterinary Medicine
Background:
- Colitis cystica profunda (CCP) is a rare benign intestinal lesion.
- CCP can clinically and radiologically resemble malignant neoplasms.
- Its etiopathogenesis is poorly understood, with theories including congenital ectopia or chronic inflammation.
Purpose of the Study:
- To review Colitis cystica profunda (CCP) in both human and animal subjects.
- To discuss the potential etiopathogenesis of CCP.
- To explore viable animal models for studying CCP.
Main Methods:
- Literature review of Colitis cystica profunda (CCP) cases in humans and animals.
- Analysis of reported etiopathogenic factors.
- Evaluation of existing and potential animal models.
Main Results:
- CCP is a rare benign lesion with malignant mimicry.
- Congenital ectopia and chronic inflammation are suspected causes.
- Sporadic animal cases exist, but no established models are available.
Conclusions:
- Further research into CCP etiopathogenesis is needed.
- Development of animal models is crucial for understanding and treating CCP.
- Distinguishing CCP from malignancy remains a clinical challenge.
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