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Growth, Purification, and Titration of Oncolytic Herpes Simplex Virus

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Decreasing Herpes Simplex Virus (HSV) Testing Turnaround Time for Infants in a Hospital Setting: A Continuous Quality

Miranda J Reid, Peter S Chang, Stacey G Beal

Joint Commission Journal on Quality and Patient Safety

|June 25, 2026

Summary

Increasing herpes simplex virus (HSV) lab processing frequency significantly reduced test turnaround times (TAT) and length of stay (LOS) for febrile infants. This improvement in HSV diagnostics also led to a decrease in hospitalization costs.

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Area of Science:

Medical Diagnostics
Infectious Disease Management
Healthcare Operations

Background:

Febrile infants often require hospitalization and antiviral treatment pending herpes simplex virus (HSV) diagnosis.
Current diagnostic processes can lead to prolonged hospital stays and increased costs.

Purpose of the Study:

To decrease length of stay (LOS), direct hospitalization costs, and lab turnaround time (TAT) for febrile infants by increasing HSV lab processing frequency.

Main Methods:

Three Plan-Do-Study-Act (PDSA) cycles were implemented to incrementally increase HSV testing frequency.
Data on patient LOS, TAT, and direct care costs were extracted from electronic medical records.
Statistical analysis using Kruskal-Wallis and Dunn Tests compared outcomes between PDSA cycles.

Main Results:

Turnaround time (TAT) for HSV testing decreased significantly, from over 30 hours to under 6 hours.
Median length of stay (LOS) for febrile infants reduced from 2.4 to 1.9 days.
Direct care costs saw a moderate decrease, from $4,348 to $4,164.

Conclusions:

Increased HSV lab processing frequency effectively reduces TAT and LOS in febrile infants.
While cost reductions were moderate, the improvements in diagnostic efficiency enhance patient care.
Collaborative efforts between pediatric and pathology departments can optimize care for febrile infants nationwide.