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Updated: Jun 27, 2026
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Recording and Analyzing Multimodal Large-Scale Neuronal Ensemble Dynamics on CMOS-Integrated High-Density Microelectrode Array
Published on: March 8, 2024
Multiscale structural connectome eigenmodes constrain human brain functional dynamics
Jie Xia1,2,3,4, Siqi Yang5, Jinpeng Niu4
1Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, PR China.
Communications Biology
|June 25, 2026
Summary
The human brain
Area of Science:
- Neuroscience
- Computational Neuroscience
- Systems Neuroscience
Background:
- The human brain exhibits complex structural organization across multiple scales.
- Understanding how this multiscale structure influences brain function is crucial but remains challenging.
Purpose of the Study:
- To investigate the structure-function relationship in the human brain.
- To construct and analyze an in vivo multiscale structural connectome.
Main Methods:
- Integration of white matter tractography, microstructural similarity, and cortico-cortical proximity.
- Utilizing multiscale structural connectome eigenmodes to model functional activity.
- Analysis of structure-function decoupling across cortical regions.
Main Results:
- Multiscale structural connectome eigenmodes better capture spontaneous and task-evoked functional activity than conventional methods.
- A novel organizational axis of structure-function decoupling was identified, from sensory to association cortices.
- Decoupled patterns correlate with specific neurochemical and transcriptomic signatures.
Conclusions:
- Multiscale structural wiring plays a critical role in shaping brain functional dynamics.
- Novel neurobiological insights into the brain's structure-function relationship were provided.
