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Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...

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Breaking barriers: Implementation of a tuberculosis preventive treatment protocol among newly eligible populations with promising results.

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Related Experiment Video

Updated: Jun 27, 2026

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
12:36

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

Intersection Between Systemic Autoimmune Diseases, Primary Immunodeficiency and Cancer: a Field in its Infancy.

Silvia Sánchez-Ramón1,2, Ana Isabel Ramos-Lisbona3, Mohammed Yousuf Karim4

  • 1Department of Immunology, Hospital Clínico San Carlos, Madrid, 28040, Spain. ssramon@salud.madrid.org.

Journal of Clinical Immunology
|June 25, 2026
PubMed
Summary

Systemic autoimmune diseases and primary immunodeficiencies/inborn errors of immunity (PIDs/IEIs) share immune dysregulation, challenging traditional views. Recognizing PIDs/IEIs is crucial for accurate diagnosis and safe treatment, improving patient outcomes.

Keywords:
Autoimmune systemic diseasesImmune dysregulationInborn errors of immunityMalignancy riskPrecision medicine

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Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity
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Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

Published on: April 11, 2019

Related Experiment Videos

Last Updated: Jun 27, 2026

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
12:36

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity
11:12

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

Published on: April 11, 2019

Area of Science:

  • Immunology
  • Genetics
  • Oncology

Background:

  • Traditionally, systemic autoimmune diseases and primary immunodeficiencies/inborn errors of immunity (PIDs/IEIs) were considered distinct immunological entities.
  • Emerging evidence reveals a spectrum of immune dysregulation and genetic vulnerability shared between these conditions.
  • Advances in genetic sequencing identify monogenic IEIs with autoimmune features, blurring diagnostic lines.

Purpose of the Study:

  • To review the intricate relationships between autoimmunity, immunodeficiency, and malignancy.
  • To emphasize how immune dysregulation contributes to susceptibility to infections, cancer, and treatment complications.
  • To explore the diagnostic and therapeutic implications of overlapping phenotypes.

Main Methods:

  • A narrative literature review was conducted.
  • The review focused on underlying mechanisms, clinical manifestations, and management strategies.
  • Key areas included genetic insights, immunological screening, and cancer risk.

Main Results:

  • Immune dysregulation is central to susceptibility to infections, cancer, and treatment-related issues.
  • Unrecognized PIDs/IEIs can lead to misdiagnosis and harmful treatment escalation in autoimmune diseases.
  • Immunological screening and genetic profiling are vital for accurate diagnosis and tailored therapies.
  • Malignancy serves as a critical intersection, with cancer patterns reflecting distinct pathogenic mechanisms.

Conclusions:

  • Integrating mechanistic understanding and genetic data facilitates a precision medicine approach.
  • Optimizing treatment efficacy while minimizing harm is achievable across the immunological continuum.
  • Prompt immunological screening is essential for patients with atypical autoimmune presentations.