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Persistent placoid maculopathy: long term outcomes and prognostic factors.
Claire Seppey1, Eirini Kaisari1, Mickael Anjou2
1Hôpital ophtalmique Jules-Gonin, Fondation Asile des Aveugles, Department of Ophthalmology, Université de Lausanne, Lausanne, Switzerland.
Retina (Philadelphia, Pa.)
|June 26, 2026
Summary
Persistent placoid maculopathy (PPM) often leads to severe vision loss and complications like choroidal neovascularization. Systemic treatment is linked to better visual outcomes in patients with this condition.
Area of Science:
- Ophthalmology
- Retinal Diseases
- Vascular Diseases
Background:
- Persistent placoid maculopathy (PPM) is an inflammatory condition affecting the macula.
- Long-term outcomes and systemic associations require further investigation.
Purpose of the Study:
- To assess long-term visual results, recurrence, complications, and systemic links of PPM.
- To identify predictors of final visual acuity in PPM patients.
Main Methods:
- A retrospective multicenter case series combined with a systematic literature review.
- Included patients with bilateral placoid macular lesions and multimodal imaging, with ≥23 months follow-up.
Main Results:
- One-third of eyes experienced severe visual loss (<20/100).
- Choroidal neovascularization (65.2%) and recurrence (21.7%) were common.
- Systemic cardiovascular comorbidities (87.5%) and cerebral vasculitis were noted. Systemic treatment correlated with better final visual acuity (p=0.014).
Conclusions:
- PPM has a high complication rate and poor visual prognosis.
- Systemic treatment showed a significant association with improved final visual acuity.
