Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
Imaging Studies for Cardiovascular System V: CT01:28

Imaging Studies for Cardiovascular System V: CT

Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
Imaging Studies for Cardiovascular System II:Types of Echocardiography01:20

Imaging Studies for Cardiovascular System II:Types of Echocardiography

Echocardiography plays a role in assessing cardiac health and detecting heart conditions, with various types providing critical insights for diagnosis and treatment.
Types of Echocardiography
Transthoracic Echocardiography (TTE)
TTE is the most common type of echocardiogram which involves placing a transducer on the patient's chest, emitting sound waves to create heart images. TTE is invaluable for evaluating the heart's size, structure, and motion, making it particularly useful for diagnosing...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Number needed to treat and harm for lecanemab and donanemab in early Alzheimer disease.

Journal of neurology·2026
Same author

Understanding CT Perfusion in Acute Ischemic Stroke: How Algorithms Shape Perfusion Maps.

Diagnostics (Basel, Switzerland)·2026
Same author

Pooling Alzheimer's disease: when methodological rigor risks obscuring biological complexity.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2026
Same author

Regional brain atrophy, white matter lesions, and functional outcome after endovascular thrombectomy for acute ischemic stroke.

Journal of neurointerventional surgery·2026
Same author

Sequential contrast-enhanced ultrasound assessment of intraplaque enhancement in carotid plaques.

Journal of ultrasound·2026
Same author

Abuse in individuals with multiple sclerosis: the SocialMS Italian study.

Multiple sclerosis and related disorders·2026
Same journal

Correction: Luca et al. Global and Regional Diagnostic Results of Progress Toward Cervical Cancer Elimination, According to the WHO Strategy: A Systematic Literature Review with Narrative Synthesis. <i>Diagnostics</i> 2026, <i>16</i>, 1224.

Diagnostics (Basel, Switzerland)·2026
Same journal

Association Between Systemic Inflammatory Response Biomarkers and Disease Activity in Systemic Lupus Erythematosus: A Multi-Center Retrospective Study.

Diagnostics (Basel, Switzerland)·2026
Same journal

Vertebrogenic Low Back Pain and Basivertebral Nerve Ablation: A Review of Mechanisms, Imaging-Driven Selection, and Clinical Outcomes.

Diagnostics (Basel, Switzerland)·2026
Same journal

Multivalvular Carcinoid Heart Disease: The Role of Echocardiography in Diagnosis and Selection for Heterotopic Bicaval Valve Implantation.

Diagnostics (Basel, Switzerland)·2026
Same journal

Data-Efficient and Explainable Multimodal Survival Prediction in NSCLC Using Deep Image Embeddings, Clinical Variables, and Gradient-Boosted Trees.

Diagnostics (Basel, Switzerland)·2026
Same journal

Anomalous Left Coronary Artery from the Pulmonary Artery: Cinematic Volume Rendering Technique for Enhanced Anatomic Visualization.

Diagnostics (Basel, Switzerland)·2026
See all related articles

Related Experiment Video

Updated: Jun 27, 2026

A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis
09:36

A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis

Published on: August 12, 2025

Dynamic Contrast-Enhanced Ultrasound for Carotid Plaque Characterization: An Algorithm-Aware Technical Review.

Nicola Morelli1, Marco Spallazzi2, Marina Biondi1

  • 1Neuroradiology Unit, Guglielmo da Saliceto Hospital, 29121 Piacenza, Italy.

Diagnostics (Basel, Switzerland)
|June 26, 2026
PubMed
Summary
This summary is machine-generated.

Dynamic contrast-enhanced ultrasound (DCE-US) offers a radiation-free method for assessing carotid artery disease plaque vulnerability. This review clarifies analytical approaches for DCE-US, promoting reproducible plaque characterization.

Keywords:
carotid plaquecontrast-enhanced ultrasounddynamic contrast-enhanced ultrasoundimaging biomarkersintraplaque neovascularizationquantitative plaque characterizationsignal modeling

More Related Videos

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology
09:33

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology

Published on: February 7, 2015

Related Experiment Videos

Last Updated: Jun 27, 2026

A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis
09:36

A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis

Published on: August 12, 2025

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology
09:33

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology

Published on: February 7, 2015

Area of Science:

  • Vascular Imaging
  • Medical Ultrasound
  • Cardiovascular Disease

Background:

  • Carotid artery disease assessment traditionally relies on luminal stenosis, but plaque vulnerability is crucial for risk stratification.
  • Intraplaque neovascularization indicates plaque instability, linked to inflammation and hemorrhage.
  • Dynamic contrast-enhanced ultrasound (DCE-US) using microbubble agents provides real-time, radiation-free assessment of plaque neovascularization.

Purpose of the Study:

  • To clarify analytical approaches in carotid DCE-US for plaque characterization.
  • To distinguish between bolus-based and destruction-replenishment modeling methods.
  • To provide practical principles for reproducible DCE-US acquisition, analysis, and reporting.

Main Methods:

  • Review of analytical methods for carotid DCE-US, including bolus-based wash-in/wash-out and destruction-replenishment modeling.
  • Discussion of parameters derived from each analytical approach (e.g., peak intensity, wash-in slope, replenishment rate).
  • Emphasis on operational meaning of parameters, model assumptions, and methodological considerations (ROI placement, motion correction, acoustic settings).

Main Results:

  • DCE-US analysis involves distinct kinetic regimes (bolus vs. destruction-replenishment) yielding non-interchangeable parameters.
  • Understanding analytical assumptions and methodological choices is critical for interpreting quantitative and semi-quantitative parameters.
  • Practical principles are provided to enhance transparency and reproducibility in carotid plaque characterization via DCE-US.

Conclusions:

  • Standardization of DCE-US acquisition and analysis is needed for reliable carotid plaque characterization.
  • The review aims to foster a transparent, reproducible, and biologically coherent approach to quantitative plaque analysis.
  • This technical review guides specialists in understanding and applying DCE-US for improved assessment of carotid artery disease vulnerability.