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Pseudofracture: An Acute Peripheral Tissue Trauma Model
10:08

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Published on: April 18, 2011

Persistent CRP Elevation at 4 Weeks Is Associated with Delayed Union After Polytrauma: An Exploratory Retrospective

Eduard Catalin Georgescu1,2, Ioana Anca Badarau3, Alexandru Lisias Dimitriu1,2

  • 1Department 14-Orthopaedics and Intensive Care, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.

Diagnostics (Basel, Switzerland)
|June 26, 2026
PubMed
Summary

Persistent C-reactive protein (CRP) elevation at 4 weeks post-injury is linked to delayed bone healing in polytrauma patients. This finding suggests CRP may indicate complications, but requires further validation for predictive use.

Keywords:
C-reactive proteindelayed unionfracture healinginflammatory biomarkersinterleukin-6long-bone fracturesmRUSTpolytrauma

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Area of Science:

  • Orthopedic Surgery
  • Trauma Care
  • Biomarker Research

Background:

  • Delayed bone healing is a significant complication in polytrauma patients.
  • Systemic inflammation and physiological stress impact fracture repair.
  • The role of inflammatory markers in predicting healing outcomes needs further investigation.

Purpose of the Study:

  • To evaluate the association between serial changes in interleukin-6 (IL-6), C-reactive protein (CRP), and fibrinogen and delayed union in polytrauma patients.
  • To identify potential biomarkers for predicting delayed fracture healing.

Main Methods:

  • Retrospective cohort study of 115 adult polytrauma patients with long-bone fractures.
  • Serial measurements of IL-6, CRP, and fibrinogen at multiple time points post-injury.
  • Radiographic assessment of bone healing and clinician-assigned delayed union as primary endpoint.

Main Results:

  • Delayed union occurred in 33.9% of patients.
  • Persistent elevation of CRP at 4 weeks post-injury was independently associated with delayed union (adjusted OR 2.16).
  • IL-6 findings were less consistent, and fibrinogen was not significantly associated.

Conclusions:

  • Post-traumatic CRP elevation at 4 weeks is associated with delayed union in polytrauma patients.
  • CRP may indicate delayed healing, infection, or other inflammatory complications.
  • Prospective validation is needed to confirm CRP's predictive value for fracture healing.