Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jun 27, 2026

$Multifractal Spectrum Analysis for Assessing Pulmonary Nodule Malignancy$

Multifractal Spectrum Analysis for Assessing Pulmonary Nodule Malignancy

Published on: January 10, 2025

Biomarkers for Lung Nodule Risk Stratification: Are We There Yet?

Sushan Gupta¹, Swati Jain¹, Krupa Shingada¹

¹Department of Pulmonary & Critical Care, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

Diagnostics (Basel, Switzerland)

|June 26, 2026

Summary

Stratifying indeterminate pulmonary nodules (IPNs) is difficult. Current methods like clinical gestalt lead to unnecessary biopsies, while validated risk calculators are cumbersome, highlighting the need for better lung cancer risk assessment tools.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Potential Dupilumab-Induced Unmasking of Specific Immunoglobulin Deficiency: A First-of-Its-Kind Case.

Case reports in pulmonology·2026

Same author

The role of Sodium-Glucose Transporter-2 Inhibitors (SGLT-2i) in preventing chronic obstructive disease exacerbation in patients with diabetes and COPD: An electronic health database analysis.

Heart & lung : the journal of critical care·2024

Same author

World Association for Bronchology and Interventional Pulmonology (WABIP) guidelines on airway stenting for malignant central airway obstruction.

Respirology (Carlton, Vic.)·2024

Same author

Long-term outcomes and predictors of mortality in patients with pulmonary embolism undergoing catheter-directed thrombolysis: a 10-year retrospective study.

Current problems in cardiology·2024

Same author

Pulmonary Langerhans Cell Histiocytosis: An Unusual Differential for a Solitary Lung Nodule.

Case reports in pulmonology·2024

Same author

Vasoreactive pulmonary artery hypertension in non-fibrotic hypersensitive pneumonitis.

BMJ case reports·2024

Area of Science:

Pulmonology
Oncology
Radiology

Background:

Increasing detection of pulmonary nodules, with most being indeterminate.
Challenges in accurately stratifying indeterminate pulmonary nodules (IPNs).
Current reliance on clinical gestalt leads to unnecessary invasive procedures.

Purpose of the Study:

To address the challenges in stratifying indeterminate pulmonary nodules.
To explore alternatives to clinical gestalt for risk assessment.
To evaluate the role of lung cancer risk biomarkers.

Main Methods:

Review of current clinical practices for pulmonary nodule assessment.
Discussion of limitations of existing risk calculators and biomarkers.
Anticipation of upcoming multicenter trials for data generation.

Keywords:

biomarker lung nodules pulmonary nodules risk stratification

Related Experiment Videos

Last Updated: Jun 27, 2026

$Multifractal Spectrum Analysis for Assessing Pulmonary Nodule Malignancy$

Multifractal Spectrum Analysis for Assessing Pulmonary Nodule Malignancy

Published on: January 10, 2025

Main Results:

Most indeterminate pulmonary nodules are benign, yet stratification is challenging.
Validated risk calculators are not routinely used due to complexity.
Commercially available biomarkers have limitations and lack guideline support.

Conclusions:

Clinical gestalt for IPN assessment is suboptimal, leading to potential harm.
Barriers to biomarker adoption include lack of evidence and clinical inertia.
Future multicenter trials are expected to provide data for guideline incorporation and improved clinical utility.