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Related Concept Videos

Genital Herpes01:23

Genital Herpes

Genital herpes is a sexually transmitted infection primarily caused by herpes simplex virus type 2 (HSV-2), though herpes simplex virus type 1 (HSV-1) is increasingly implicated in genital infections, particularly among younger populations. Transmission occurs mainly through sexual contact, with asymptomatic viral shedding serving as a major route of spread. This characteristic makes HSV-2 difficult to control at a population level, as individuals may unknowingly transmit the virus even in the...
Sexually Transmitted Infections01:26

Sexually Transmitted Infections

Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...

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Related Experiment Video

Updated: Jun 27, 2026

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis
06:57

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis

Published on: June 14, 2019

Integrated Cervical Self-Sampling for Cytology, High-Risk Human Papillomavirus, and Sexually Transmitted Infection

Chang Gok Woo1,2, Jaehoon Choi1,2, Yujin Im1,2

  • 1Department of Pathology, College of Medicine, Chungbuk National University, Cheongju 28644, Republic of Korea.

Diagnostics (Basel, Switzerland)
|June 26, 2026
PubMed
Summary

Cervical self-sampling for liquid-based cytology (LBC), high-risk human papillomavirus (hrHPV), and sexually transmitted infections (STIs) showed high feasibility and agreement with clinician methods. This integrated approach can improve cervical cancer screening efficiency and accessibility.

Keywords:
cervical cancer screeningcytologyhuman papillomaviruspreventive medicineself-samplingsexually transmitted infections

Related Experiment Videos

Last Updated: Jun 27, 2026

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis
06:57

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis

Published on: June 14, 2019

Area of Science:

  • Gynecology
  • Public Health
  • Infectious Diseases

Background:

  • Cervical self-sampling is gaining traction for high-risk human papillomavirus (hrHPV) detection.
  • Limited evidence exists for integrated testing of liquid-based cytology (LBC) and sexually transmitted infections (STIs) using self-sampling methods.

Purpose of the Study:

  • To evaluate the feasibility and diagnostic agreement of a novel, single-step integrated self-sampling approach for LBC, hrHPV, and STI testing.
  • To compare self-collected specimens with clinician-collected specimens in a prospective paired study.

Main Methods:

  • Prospective paired study involving 520 Korean women undergoing cervical cancer screening.
  • Participants performed self-sampling using Earlypap®, followed by clinician-collected sampling.
  • Paired specimens were analyzed for LBC, hrHPV, and STI detection, with agreement assessed using Cohen's kappa coefficients.

Main Results:

  • First-attempt self-sampling success rate was 98.5%, with 92.1% of participants preferring it over clinician-collection.
  • High agreement was observed: 91.7% (κ = 0.67) for LBC, 95.4% (κ = 0.79) for hrHPV, and 97.0% (κ = 0.72) for STI.
  • hrHPV positivity was 14.8% in self-collected vs. 12.9% in clinician-collected specimens; common STIs like Ureaplasma spp. and Candida albicans were detected.

Conclusions:

  • Integrated cervical self-sampling using a single-step device is highly feasible and demonstrates substantial agreement with clinician-based methods.
  • This approach shows potential for enhancing cervical cancer screening efficiency.
  • It may also help reduce participation barriers, thereby improving screening accessibility.