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Generation and 3-Dimensional Quantitation of Arterial Lesions in Mice Using Optical Projection Tomography
Published on: May 26, 2015
Photonic Methods for the Assessment of Lesion Activity.
1Department of Preventive and Restorative Dental Sciences, University of California, San Francisco, 707 Parnassus Ave, San Francisco, CA 94143, USA.
Diagnostics (Basel, Switzerland)
|June 26, 2026
Summary
New photonic methods, including optical coherence tomography (OCT) and short-wavelength infrared (SWIR) reflectance, can accurately assess dental caries activity. These techniques help differentiate active lesions from inactive ones, guiding treatment decisions and preventing unnecessary dental procedures.
Area of Science:
- Dental Diagnostics
- Biophotonics
- Caries Research
Background:
- Current methods for assessing dental caries activity are unreliable.
- Many non-cavitated lesions do not require intervention, necessitating accurate activity assessment.
- Photonic-based approaches offer non-destructive monitoring of lesion progression.
Purpose of the Study:
- To review the advantages of novel photonic-based techniques for assessing dental caries activity.
- To highlight the need for improved in vivo diagnostic tools for dental caries.
- To explore optical methods for differentiating active from arrested caries lesions.
Main Methods:
- Review of photonic-based diagnostic approaches including optical coherence tomography (OCT), Raman imaging, and fluorescence loss.
- Analysis of thermal and short-wavelength infrared (SWIR) reflectance measurements during lesion dehydration.
- Evaluation of non-destructive optical monitoring of lesion structure and light scattering changes.
Main Results:
- Optical coherence tomography (OCT) demonstrates distinct structural differences between active and arrested caries lesions.
- Short-wavelength infrared (SWIR) reflectance measurements during dehydration show promise for assessing lesion activity.
- Optical diagnostic instruments exploit changes in lesion porosity and permeability for activity assessment.
Conclusions:
- OCT and SWIR dehydration imaging show significant potential for assessing caries activity.
- These photonic methods can be used for caries screening and safe, frequent monitoring.
- The techniques do not require the application of external agents, offering a non-invasive diagnostic approach.

