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Updated: Jun 27, 2026
03:38
Unilateral Lung Volume Analysis Using Micro-CT for Enhanced Assessment of Pulmonary Fibrosis in Preclinical Models
Published on: June 20, 2025
Antibiotic-Induced Pulmonary Fibrosis: National Database Analysis
Olga Butranova1, Yury Kustov1, Anna Abramova1
1Department of General and Clinical Pharmacology, Peoples' Friendship University of Russia Named After Patrice Lumumba (RUDN), 6 Miklukho-Maklaya St., 117198 Moscow, Russia.
Biomedicines
|June 26, 2026
Summary
Cefuroxime shows a strong safety signal for drug-induced pulmonary fibrosis (DIPF). Further research is needed to confirm causality, as other antibacterials also warrant attention.
Area of Science:
- Pharmacovigilance
- Pulmonary Medicine
- Drug Safety
Background:
- Pulmonary fibrosis (PF) is a significant global health concern.
- Drug-induced lung injury (DILI) is a key factor in PF development.
- Antimicrobial agents are among the drugs implicated in DILI.
Purpose of the Study:
- To analyze antibacterial agents associated with drug-induced pulmonary fibrosis (DIPF).
- To evaluate safety signals for DIPF using spontaneous reports.
- To calculate reporting odds ratio (ROR) and proportional reporting ratio (PRR).
Main Methods:
- Retrospective, descriptive pharmacoepidemiological analysis.
- Utilized spontaneous reports from the Russian National Pharmacovigilance database (AIS).
- Analyzed data from April 2019 to March 2025.
Main Results:
- Identified 130 spontaneous reports of DIPF linked to antibacterials.
- Cefuroxime demonstrated the strongest association with DIPF (PRR=15.11, ROR=15.31).
- Other implicated antibacterials included sulfamethoxazole, azithromycin, levofloxacin, and doxycycline.
Conclusions:
- Cefuroxime presents a robust, unexpected safety signal for DIPF.
- Findings suggest potential protopathic bias or context-dependent effects.
- Further prospective studies are required to validate these safety signals and explore causality.
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