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Vitamin D Status and Reproductive Hormonal Profiles in Early Versus Physiological Menopause: A Comparative
Anamaria Ardelean1,2, Cristian Furău1,2, Oana Toduț1,2
1Multidisciplinary Doctoral School, "Vasile Goldis" Western University of Arad, 310414 Arad, Romania.
Biomedicines
|June 26, 2026
Summary
This study found that while women with early menopause often have low vitamin D, serum vitamin D levels do not consistently correlate with reproductive hormone changes like estradiol or progesterone.
Area of Science:
- Endocrinology
- Reproductive Health
- Nutritional Science
Background:
- Early menopause (ages 40-45) is linked to health risks.
- Vitamin D's role in endocrine and reproductive function is under investigation.
- The benefit of vitamin D for women with early menopause remains unclear.
Purpose of the Study:
- To investigate the relationship between vitamin D levels and reproductive hormones in women with early versus physiological menopause.
- To determine if vitamin D influences hormonal changes during menopause.
Main Methods:
- Retrospective observational study of 272 women.
- Stratification into early and physiological menopause groups.
- Measurement of 25-hydroxyvitamin D (25(OH)D), estradiol, progesterone, FSH, and LH.
- Correlation and regression analyses were used.
Main Results:
- A high prevalence of vitamin D deficiency was observed in the study population.
- Women in the early menopause group had significantly lower estradiol levels.
- No consistent significant relationship was found between serum 25(OH)D and estradiol or progesterone levels overall.
Conclusions:
- Women with early or physiological menopause are susceptible to low vitamin D.
- The study did not find evidence that vitamin D significantly influences reproductive hormone levels during menopause.
- Findings suggest vitamin D is not a primary factor in menopausal hormonal shifts, requiring cautious interpretation due to inconsistent results.
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