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Related Experiment Video

Updated: Jun 27, 2026

Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography
07:18

Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography

Published on: February 18, 2022

Smaller Optic Discs Show Higher Macular Flow Density: An Optical Coherence Tomography Angiography Study.

Charlotte Egbring1, Sarah Kleemann1, Moritz Fabian Danzer2

  • 1Department of Ophthalmology, University of Muenster Medical Center, 48149 Muenster, Germany.

Biomedicines
|June 26, 2026
PubMed
Summary

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Smaller optic discs correlate with higher macular flow density (FD) in both superficial and deep capillary plexuses, according to optical coherence tomography angiography (OCT-A) data. Foveal avascular zone (FAZ) parameters were not significantly associated with optic disc size.

Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Retinal Vascular Diseases

Background:

  • Macular flow density (FD) and foveal avascular zone (FAZ) are key indicators of retinal health.
  • Optic disc size, quantified by Bruch's membrane opening area (BMOA), is a variable that may influence these parameters.
  • Understanding these relationships is crucial for establishing normative data in optical coherence tomography angiography (OCT-A).

Purpose of the Study:

  • To investigate the correlation between macular FD, FAZ characteristics, and optic disc size (BMOA).
  • To evaluate differences in FD and FAZ parameters across different optic disc size cohorts.

Main Methods:

  • Retrospective analysis of 151 healthy eyes using OCT-A.
  • Rank correlation coefficients were computed to assess associations between FD and BMOA.
Keywords:
Bruch’s membrane opening areadeep capillary plexusfoveal avascular zonemacular flow densityoptic disc sizeoptical coherence tomography angiographysuperficial capillary plexus

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Related Experiment Videos

Last Updated: Jun 27, 2026

Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography
07:18

Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography

Published on: February 18, 2022

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography
07:23

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography

Published on: March 26, 2020

Doppler Optical Coherence Tomography of Retinal Circulation
10:46

Doppler Optical Coherence Tomography of Retinal Circulation

Published on: September 18, 2012

  • FD and FAZ parameters were compared among three optic disc size groups.

    • Main Results:

    • A significant negative correlation was found between FD in several macular subsectors and BMOA.
    • Eyes with smaller optic discs showed significantly higher FD in both superficial capillary plexus (SCP) and deep capillary plexus (DCP) compared to larger discs.
    • No significant differences were observed for foveal FD, FAZ area, or FAZ perimeter across disc size groups.

    Conclusions:

    • Optic disc size is a relevant variable for normative OCT-A data.
    • Smaller optic discs are associated with higher macular FD in both SCP and DCP.
    • FAZ parameters appear to be independent of optic disc size (BMOA).