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Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
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Recent Advances in Responsive Microgels for Biomedical Application.

Hongtao Zhang1, Wenkai Zhang2, Yongfeng Gao3

  • 1School of Chemistry and Chemical Engineering, Qinghai Normal University, Xining 810008, China.

Bioengineering (Basel, Switzerland)
|June 26, 2026
PubMed
Summary
This summary is machine-generated.

Responsive microgels offer tunable properties for advanced biomedical uses. This review covers their design, synthesis, and applications in drug delivery, tissue engineering, imaging, and diagnostics.

Keywords:
controlled drug deliverydiagnosticimagingstimuli-responsive microgelstissue engineering

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Area of Science:

  • Materials Science
  • Biomedical Engineering
  • Nanotechnology

Background:

  • Responsive microgels are advanced soft materials with tunable properties.
  • Their high water content and dynamic responsiveness to stimuli make them ideal for biomedical applications.

Purpose of the Study:

  • To review recent advances in the design, synthesis, and biomedical applications of responsive microgels.
  • To highlight their functional roles in drug delivery, tissue engineering, imaging, and diagnostics.

Main Methods:

  • Literature review focusing on recent representative studies.
  • Analysis of structure-property relationships and responsiveness principles.
  • Synthesis and application examples across key biomedical domains.

Main Results:

  • Responsive microgels show promise in controlled drug delivery with stimulus-triggered release.
  • They serve as scaffolds and injectable constructs for tissue regeneration.
  • Microgels function as contrast agents and probe carriers in biomedical imaging.
  • They enable advanced diagnostics through biosensing and biomarker detection.

Conclusions:

  • Responsive microgels possess multifunctional capabilities for diverse biomedical applications.
  • Current challenges and future opportunities for clinical translation are discussed.