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Programmed Cell Death of Endothelial Cells in Ischemic Heart Disease: Mechanism and Potential Cell and Gene
Zijia Sun1, Lei Chen2,3, Yingying Cao4
1Department of Rehabilitation, Children's Hospital of Nanjing Medical University, Nanjing 210003, China.
Insights
Programmed cell death in endothelial cells contributes to ischemic heart disease (IHD). Understanding these mechanisms may reveal new cell and gene therapies for IHD treatment.
Area of Science:
- Cardiovascular Research
- Cell Biology
- Molecular Medicine
Background:
- Ischemic heart disease (IHD) is a major global cause of mortality.
- Endothelial cell (EC) programmed cell death (PCD) is a key factor in IHD, leading to microvascular issues and worsened cardiac damage.
Purpose of the Study:
- To review the molecular mechanisms of EC PCD in IHD.
- To summarize potential cell and gene therapy strategies for IHD.
Main Methods:
- Literature review of molecular mechanisms of PCD in ECs.
- Analysis of current and emerging cell and gene therapy approaches for IHD.
Main Results:
- PCD pathways in ECs are interconnected and critical for IHD progression.
- Various cell and gene therapies show promise for IHD treatment.
Conclusions:
- Targeting EC PCD pathways offers a potential therapeutic avenue for IHD.
- Cell and gene therapies represent promising strategies for managing IHD.
Abstract:
Ischemic heart disease (IHD) is the leading cause of death worldwide, accounting for over eight million deaths each year. IHD encompasses a spectrum of conditions, including atherosclerosis (AS), myocardial infarction (MI), and ischemia/reperfusion (I/R) injury. Programmed cell death (PCD) of endothelial cells (ECs) plays a critical role in IHD pathogenesis, causing microvascular dysfunction, barrier disruption and exacerbation of cardiac injury. PCD involves different signaling pathways, but they are interconnected. Therefore, it is crucial to understand the mechanisms underlying the various forms of PCD in ECs to develop therapeutic strategies for IHD. This review focuses on the molecular mechanisms of PCD of ECs in IHD and provides comprehensive summary of potential cell and gene therapy therapeutic strategies for the treatment of IHD.
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