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Related Experiment Video

Updated: Jun 27, 2026

Imaging Mitochondrial Ca2+ Uptake in Astrocytes and Neurons using Genetically Encoded Ca2+ Indicators (GECIs)
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Published on: January 22, 2022

Statin-Induced Coenzyme Q Deficiency Induces Metabolic Reprogramming in Astrocytes.

Krzysztof Wojcicki1, Lukasz Galganski1, Adrianna Budzinska1

  • 1Laboratory of Mitochondrial Biochemistry, Department of Bioenergetics, Faculty of Biology, Adam Mickiewicz University, Uniwersytetu Poznanskiego 6, 61-614 Poznan, Poland.

Antioxidants (Basel, Switzerland)
|June 26, 2026
PubMed
Summary
This summary is machine-generated.

Statins reduce coenzyme Q (CoQ) levels in astrocytes, prompting them to adapt by prioritizing antioxidant defenses over energy production. Coenzyme Q10 (CoQ10) supplementation helps restore astrocyte energy metabolism.

Keywords:
CoQ deficiencyastrocytesatorvastatinmitochondrial functionoxidative stresssimvastatin

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Published on: November 19, 2014

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Last Updated: Jun 27, 2026

Imaging Mitochondrial Ca2+ Uptake in Astrocytes and Neurons using Genetically Encoded Ca2+ Indicators (GECIs)
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Imaging Intracellular Ca2+ Signals in Striatal Astrocytes from Adult Mice Using Genetically-encoded Calcium Indicators
12:19

Imaging Intracellular Ca2+ Signals in Striatal Astrocytes from Adult Mice Using Genetically-encoded Calcium Indicators

Published on: November 19, 2014

Area of Science:

  • Neuroscience
  • Biochemistry
  • Cell Biology

Background:

  • Statins are widely prescribed cholesterol-lowering drugs.
  • Their impact on astrocyte oxidative metabolism remains unclear.

Purpose of the Study:

  • To investigate how statins affect astrocyte coenzyme Q (CoQ) homeostasis, mitochondrial function, and energy metabolism.
  • To explore the effects of CoQ10 supplementation in statin-treated astrocytes.

Main Methods:

  • Rat astrocytes were treated with atorvastatin or simvastatin.
  • Assessed CoQ levels, mitochondrial function, reactive oxygen species (ROS), antioxidant pathways, and energy metabolism.
  • Evaluated the impact of CoQ10 supplementation.

Main Results:

  • Statins reduced cellular CoQ9 and CoQ10 levels, particularly their antioxidant forms.
  • Statin treatment led to lower ROS, upregulation of NRF2-dependent pathways and HIF1α, BDNF.
  • Astrocytes exhibited glycolytic reprogramming, mitochondrial fission, and impaired oxidative phosphorylation, with reduced ATP levels.
  • CoQ10 supplementation restored ATP levels without further reducing ROS.

Conclusions:

  • Statin-induced CoQ deficiency triggers adaptive metabolic remodeling in astrocytes, prioritizing redox homeostasis over ATP production.
  • CoQ10 supplementation may support astrocyte energy metabolism under statin treatment.