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Related Concept Videos

The Skin Microbiota01:27

The Skin Microbiota

The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...
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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular cells,...
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Pharmacogenomics: Identification of New Drug Targets

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Updated: Jun 27, 2026

Visualizing and Quantifying Pharmaceutical Compounds within Skin using Coherent Raman Scattering Imaging
11:07

Visualizing and Quantifying Pharmaceutical Compounds within Skin using Coherent Raman Scattering Imaging

Published on: November 24, 2021

Sensitive Skin Improvement Through Bioinformatics-Identified Cosmetic Ingredients That Regulate Transcriptome-Derived

Seo Hyeong Kim1, Ji Hye Kim1, Ji Min Shin1

  • 1Cutis Biomedical Research Center Co., Ltd., Seoul 07327, Republic of Korea.

Biomolecules
|June 26, 2026
PubMed
Summary
This summary is machine-generated.

Researchers developed a new method to find biomarkers for sensitive skin and cosmetic ingredients that can help manage it. This approach led to a successful clinical trial showing improved skin health.

Keywords:
bioinformaticsbiomarkercosmeceuticalmicroneedlesensitive skintranscriptomics

Related Experiment Videos

Last Updated: Jun 27, 2026

Visualizing and Quantifying Pharmaceutical Compounds within Skin using Coherent Raman Scattering Imaging
11:07

Visualizing and Quantifying Pharmaceutical Compounds within Skin using Coherent Raman Scattering Imaging

Published on: November 24, 2021

Area of Science:

  • Dermatology
  • Molecular Biology
  • Cosmetic Science

Background:

  • Sensitive skin lacks objective diagnostic tools and treatments.
  • Current cosmetic development for sensitive skin relies on excluding irritants, not understanding underlying mechanisms.

Purpose of the Study:

  • To develop an integrated pipeline for identifying sensitive skin-associated inflammatory biomarkers.
  • To discover cosmetic ingredients that regulate these biomarkers.
  • To validate the pipeline through in vitro, in vivo, and clinical assessments.

Main Methods:

  • Integrated pipeline: microneedle-based skin sampling (MISSM) for transcriptome analysis, bioinformatics, in vitro validation, and clinical assessment.
  • Identification and validation of candidate biomarkers (MCOLN1, CYR61, PMAIP1, PTGS2, HMGB2) and cosmetic ingredients.
  • Development and pilot clinical trial of a prototype emulsion with longitudinal molecular monitoring via MISSM.

Main Results:

  • Sensitive skin biomarkers were significantly upregulated after lactic acid stimulation in cell models.
  • In vitro validation confirmed cosmetic ingredients that regulate these biomarkers.
  • The prototype emulsion was hypoallergenic and showed significant reduction in target biomarker expression in clinical trials, alongside improved skin hydration, barrier function, redness, and sensory reactivity.

Conclusions:

  • The integrated pipeline enables discovery of cosmetic ingredients targeting inflammatory biomarkers in sensitive skin.
  • This approach has potential applications for various inflammatory skin conditions.
  • MISSM provides a valuable tool for longitudinal molecular monitoring in clinical settings.