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Related Concept Videos

Diabetic Foot Ulcer01:31

Diabetic Foot Ulcer

Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...
Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the exudate's...
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...

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Related Experiment Video

Updated: Jun 27, 2026

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers
04:09

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers

Published on: March 3, 2023

Multifunctional Self-Pumping Janus Dressing for Exudate Management and Diabetic Wound Healing.

Yingnan Yue1, Naoyuki Chado1, Rike Rachmayati2

  • 1Department of Chemical Engineering, Faculty of Engineering, Graduate School, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan.

Biomolecules
|June 26, 2026
PubMed
Summary

A novel Cur Janus nanofibrous dressing accelerates diabetic wound healing by managing exudate and inflammation. This multifunctional dressing offers antibacterial and antioxidant properties for improved chronic wound management.

Keywords:
Janus nanofiberbioactive agent releasediabetic wound healingmulti-functional nanofibrous dressing

Related Experiment Videos

Last Updated: Jun 27, 2026

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers
04:09

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers

Published on: March 3, 2023

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Wound Healing

Background:

  • Diabetic chronic wounds present challenges due to excessive exudate and prolonged inflammation.
  • Advanced wound dressings are needed to manage complex wound microenvironments and reduce infection risk.

Purpose of the Study:

  • To develop a multifunctional Cur Janus nanofibrous dressing for diabetic chronic wound management.
  • To evaluate the wound healing, antibacterial, and anti-inflammatory properties of the Cur Janus dressing.

Main Methods:

  • Fabrication of a Janus nanofibrous dressing by integrating hydrophilic and hydrophobic layers with curcumin.
  • Assessment of unidirectional liquid transport in vitro and in vivo.
  • Evaluation of antibacterial, antioxidant, and anti-inflammatory effects in a diabetic mouse model.

Main Results:

  • The Cur Janus dressing demonstrated unidirectional liquid transport.
  • Curcumin incorporation provided antibacterial and antioxidant functionalities.
  • The dressing significantly reduced wound area, promoted M2 macrophage polarization, and accelerated healing in diabetic mice.

Conclusions:

  • The Cur Janus nanofibrous dressing is a promising multifunctional platform for diabetic wound management.
  • Its unique properties, including unidirectional fluid transport and dual drug delivery potential, enhance therapeutic outcomes.
  • This advanced wound dressing effectively modulates the inflammatory microenvironment and promotes chronic wound healing.